| Objective: Based on the analysis of clinical data of children diagnosed with short stature in the outpatient department and inpatient department of the First Affiliated Hospital of Dali University,the correlation between physical indexes and serum Vit A level and serum zinc level in children with short stature was discussed,so as to provide reference for early detection and auxiliary examination of children with short stature,so as to ensure children’s health.Methods:In this study,214 children with short stature who met the inclusion and exclusion criteria in our hospital from January 2019 to June 2022 were included as subjects.Their basic information,medical history,height,weight,serum Vit A level,serum zinc level and other relevant data were collected by using the electronic case system and analyzed by SPSS25.0.Combined with the statistical analysis results and relevant data at home and abroad,the retrospective analysis was carried out.Results: 1.There were 214 subjects in this study,including 132 males(61.7%)and82 females(38.3%),with a male to female ratio of 1.6:1;2.There were 3 cases(1.4%)in the preschool group(1-3 years old),81 cases(37.9%)in the preschool group(3-7years old),62 cases(29.0%)in the school age group(7-10 years old),and 68 cases(31.8%)in the adolescent group(10-20 years old).The children with short stature in our hospital were mainly from Dali Bai Autonomous Prefecture,followed by Lijiang City.Ethnic distribution is mainly Han ethnic group and Bai ethnic group;Among the causes of short stature,idiopathic short stature and growth hormone deficiency occupy the main positions,and the rest are physical puberty retardation and idiopathic precocious puberty.2.Among 214 children with short stature included in this study,the total serum Vit A concentration was 0.34±0.10mg/L,and there were 81 cases with insufficient serum Vit A,accounting for 37.8%.The prevalence of MVAD was 34.5% and that of VAD was3.3%.The serum Vit A concentration was weakly positively correlated with age,height,weight and IGF-1 level in children with short stature,R-values were 0.218,0.233,0.213,0.360,and P values were all < 0.05,respectively,0.001,0.001,0.002,0.000.There was a moderate positive correlation with IGFBP-3 levels(r=0.443,P=0.000 < 0.05),but no correlation with BMI(r=0.061,P=0.376 > 0.05).There was no significant difference in the number of children with insufficient serum Vit A between different gender groups(P=0.242 > 0.05).There was no significant difference in the number of children with insufficient serum Vit A in different age groups(P=0.778>0.05).There was no significant difference in the number of children with insufficient serum Vit A in different etiological groups(P=0.568>0.05).3.76 children with short stature who received serum Vit A and serum zinc levels were included in the study.The serum zinc level was 81.0 ± 21.2μg/d L,and the probability of serum zinc deficiency was 21.1%.The serum zinc level of children with short stature was weakly positively correlated with SDS of body weight(r=0.235,P=0.041 < 0.05),and weakly correlated with IGF-1 level(r=0.273,P=0.017 < 0.05),but had no correlation with age,height,weight,BMI,SDS of height and IGFBP-3.r values were 0.134,0.164,0.135,-0.042,0.141,0.092,and P values were all >0.05,which were0.247,0.157,0.244,0.716,0.223,0.432.There was no significant difference in the number of children with serum zinc deficiency between different gender groups(P=0.522 > 0.05).There was no significant difference in the number of children with serum zinc deficiency in different age groups(P=0.123>0.05).There was no significant difference in the number of children with serum zinc deficiency among different serum Vit A levels(P=0.382>0.05).There was no correlation between serum Vit A level and serum zinc level in children with short stature(r=0.134,P=0.247>0.05).Conclusions: 1.Most children with short stature in our hospital were in the early school age,and idiopathic short stature and growth hormone deficiency were the most common causes.2.The prevalence of VAD was slightly higher in children with short stature,and the serum Vit A concentration was positively correlated with age,height,weight,IGF-1level and IGFBP-3 level.3.Serum zinc level was positively correlated with SDS and IGF-1 levels of body weight,but not with age,height,weight,SDS and IGFBP-3 levels.4.There was no statistical significance in zinc deficiency rate under different serum Vit A levels in children with short stature,and there was no correlation between serum Vit A level and serum zinc level in children with short stature. |
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