| Objective:1.To investigate and analyze the clinical characteristics of patients with rose acne in Dali,Yunnan,and to explore the various factors affecting the occurrence and development of the disease,so as to provide some clues for diagnosis and treatment,and guide clinical prevention of rose acne occurrence and development.2.To observe the safety and efficacy of compound glycyrrhizin injection combined with botulinum toxin A in the treatment of rose acne and to provide evidence for clinical treatment.Methods:1.A questionnaire survey was conducted on 120 patients with rose acne who were treated in the Department of Dermatology,the first affiliated Hospital of Dali University from September 2021 to October 2022.The contents of the survey included general conditions,clinical manifestations,inducing or aggravating factors of the disease,previous diagnosis and treatment history,concomitant diseases,anxiety and depression,and descriptive analysis of the results.2.Forty patients who met the inclusion criteria were randomly divided into experimental group(n = 20)and control group(n = 20).The experimental group was treated with compound glycyrrhizin injection combined with botulinum toxin A,while the control group was treated with botulinum toxin A.Both groups were treated twice with an interval of 15 days.The treatment effect was followed up at the 12 th week,and the curative effect was compared with that before treatment.The indexes were subjective DLQI,subjective symptom score,objective clinical symptom score of rose acne and VISIA red value.Results:1.General situation:(1)120 patients with rose acne occurred between 20 and 50 years old(76.66%),mainly female(85.00%).(2)facial cleansing mainly used facial cleanser(71.67%),65.83% of the patients cleansed more than or equal to twice a day.(3)24.17%of the patients did not use moisturizing products to protect their skin.(4)17.50% of the patients had no sunscreen measures in their daily life.2.Clinical manifestations:(1)the main types of skin lesions were erythema telangiectasia(60.003%)and papular pustular type(20.83%);The most common lesions were paroxysmal flushing(68.33%)and erythema(73.33%);The main distribution sites were cheeks(79.17%)and nose(75.00%);The main symptoms were dryness,tension(58.33%)and burning(56.67%).(2)the course of disease was less than 3 years(65.00%).(3)the main skin types of Fitzpatrick were type III(45.00%)and type IV(40.005%).(4)the patients with positive hair follicle demodex test accounted for41.67%.3.Other factors:(1)the inducing or aggravating factors of disease were sun exposure(70.003%),sleep(60.83%)and diet(56.67%).(2)antibiotics(39.17%)and glucocorticoids(28.33%)were the most commonly used in previous diagnosis and treatment.(3)digestive system diseases(5.83%)were the most common.(4)anxiety(41.67%)and depression(43.33%)were serious.4.Comparison of the curative effect between the experimental group and the control group:(1)after two times of treatment,the red flush,erythema,telangiectasia,papules and pustules,subjective symptoms and DLQI scores in the two groups were lower than those before treatment,and the red values of VISIA were higher than those before treatment.(2)Compared between the two groups,the scores of flushing,erythema,subjective symptoms and DLQI in the experimental group were lower than those in the control group,while the red value of VISIA in the experimental group was higher than that in the control group.(3)There was no significant difference in pain score between the two groups(P > 0.05).(4)but the satisfaction score in the experimental group was significantly higher than that in the control group(P < 0.05).(5)There were no adverse reactions such as swelling,subcutaneous ecchymosis,infection and scar formation in both groups.Conclusion:1.In this study,120 cases of rose acne patients with incorrect skin care is an important inducement of the disease,sun exposure,diet,sleep are important influencing factors,strict control of the above situation is of great significance.Rose acne can occur in combination with other systemic diseases,and the concomitant rate of anxiety and depression is also very high,which should be paid attention to in diagnosis and treatment.External application of antibiotics and hormone ointment is more common in the history of diagnosis and treatment,so doctors and nurses should strengthen their understanding of the disease.2.Compound glycyrrhizin injection combined with botulinum toxin type A can significantly improve flushing,erythema,papular pustules,telangiectasia and relieve subjective symptoms in patients with rosette acne.Moreover,the improvement of flushing,erythema and subjective symptoms was better than that of botulinum toxin alone,and there was no adverse reaction. |
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