The Efficacy And Safety Of Low-intensity,Single-wavelength Red Light In The Control Of Myopia In School-age Children

Objective:The efficacy of low-intensity single-wavelength red light in the control of myopia in school-age children was evaluated by the changes of ocular biological parameters such as axial length(axial length,AL)and spherical equivalent(spherical equivalent,SE);optical coherence tomography angiography(optical coherence tomography angiography,OCTA)was used to evaluate the effects of low-intensity single-wavelength red light on macular retinal thickness and microvascular system,so as to further evaluate the safety of low-intensity single-wavelength red light therapy.Methods:This study is a prospective study.Atotal of myopic school-age children 75cases(150 eyes)aged 7-14 years who were diagnosed as binocular ametropia in the Department of Ophthalmology,the First Affiliated Hospital of Gannan Medical University from January 2022 to August 2022 were randomly divided into experimental group and control group.55 cases(110 eyes)in the experimental group and 22 cases(40 eyes)in the control group.The experimental group wore glasses combined with low-intensity single-wavelength red light therapy apparatus to correct ametropia,while the control group only wore glasses to correct ametropia.Comprehensive ophthalmic examinations including slit lamp,intraocular pressure,uncorrected visual acuity,best corrected visual acuity,AL,SE,mydriasis optometry and fundus were performed before treatment,1 month after treatment,3 months after treatment and 6 months after treatment.In addition,6mm × 6mm macular scanning was performed on the experimental group by optical coherence tomography.By ImageJ analysis,the retinal superficial capillary plexus(superficial capillary plexus,SCP),the inner retinal thickness and the thickness of whole retina(retinal thickness,RT)were obtained.All data were statistically processed by SPSS24.0 software,and the results of all quantitative variables(including AL,SE,SCP and RT)were expressed as mean ± standard deviation(x±s);gender was expressed as a percentage.The average value and standard deviation of continuous variables are calculated,while the frequency and percentage of classified variables are calculated.The repeated measurement data(AL,SE,SCP and RT)were analyzed by repeated measurement analysis of variance,P<0.05 indicates that the difference is statistically significant.Results:1.The change data of AL showed that the AL of the experimental group at 6 months after treatment was significantly different from that before treatment and 1 month after treatment(P1,P2<0.05).In the control group,the AL of the control group at 6 months after treatment was significantly different from that before treatment,1 month and 3 months after treatment(P1,P2,P3<0.05).The AL of the eye showed a downward trend in the experimental group and an increasing trend in the control group.2.The change data of SE showed that the SE degree of the experimental group at 6 months after treatment was significantly different from that before treatment and 1 month after treatment(P1,P2<0.05).The SE of the control group at 6 months after treatment was significantly different from that before treatment,1 month and 3 months after treatment(P1,P2,P3<0.05).The SE showed a downward trend in the experimental group and an increasing trend in the control group.3.The change data of RT of macular inner layer showed that the RT of all macular zones in the experimental group at 6 months after treatment was thicker than that before treatment,and the difference was statistically significant(P<0.05).4.The change data of RT of macular full-layer showed that the RT of all macular zones in the experimental group at 6 months after treatment was thicker than that before treatment,and the difference was statistically significant(P<0.05).5.The change data of retinal SCP in macular area showed that the retinal SCP in the outer temporal region,outer inferior region and inner inferior region of macular zones in the experimental group at 6 months after treatment was significantly lower than that before treatment,the difference was statistically significant(P<0.05),but the other five zones had no significant change compared with that before treatment,and the difference was not statistically significant(P>0.05).Conclusion:Low-intensity single-wavelength red light therapy has good efficacy and safety.After red light therapy,the AL of some school-age children with myopia regressed and the SE decreased,suggesting that low-intensity single-wavelength red light therapy may have a certain effect on controlling the progression of myopia.In addition,OCTA provides quantitative information about RT and SCP in each macular area.According to the data of this study,low-intensity single-wavelength red light therapy has no significant adverse effect on macular microcirculatory system,and increases macular retinal thickness to some extent.