Diagnostic Value And Influencing Factors Of Gastrin And Pepsinogen In Chronic Gastritis And Gastric Ulcer

Objective To study the differences in the levels of Pepsinogen I,Pepsinogen II,Ratio of PepsinogenⅠ/PepsinogenⅡ,gastrin-17 in chronic gastritis and gastric ulcer and the factors affecting them,as well as the diagnostic value of the above indicators for atypical hyperplastic lesions in the stomach.Method To collect the general and clinical data of all the patients with perfect medical record data stored in the electronic medical record system of the Affiliated Hospital of Inner Mongolia Medical University.Patients were then divided into chronic Atrophic gastritis,chronic antral Atrophic gastritis,chronic total Atrophic gastritis,and gastric ulcer groups based on the endoscopic or pathological findings.And then all data were Statistically analyzed.Results(1)General data: A total of 651 patients were enrolled in this study after screening by admision criteria.There were 336(51.6%)male cases and 315(48.4%)female cases,with the ratio of male to female is about 1.07:1.The difference was statistically significant between gender groups.The age range enrolled was 19-89 years,with an average of 58.09±12.573 years,and the difference was statistically significant(P < 0.05).There were 460(70.7%)Hp-positive patients in the total sample,and the difference in Hp infection rate between the groups was statistically significant(P<0.05).(2)Clinical information:Serum PGⅠ,PGⅡ and G-17 levels were higher in the Hp-positive group compared with the Hp-negative group,and the difference was statistically significant(P < 0.05);PGR levels were lower,and the difference was statistically significant(P<0.01).In the comparison among the groups with chronic gastritis,serum PGⅠ levels,G-17 and PGR levels decreased significantly with the increase of atrophy(P<0.05);serum PGⅡ levels did not show any significant difference in the comparison among the groups(P>0.05).In contrast,serum PGⅠ,PGⅡ and G-17 levels increased and PGR levels decreased in the gastric ulcer group compared with the chronic non-contractile gastritis group,with statistically significant differences(P < 0.05).Serum PGⅠ and PGⅡ levels were higher in men than in women,and PGR levels were lower,with statistically significant differences(P<0.05);no significant differences were seen in serum G-17 levels(P>0.05).Age,smoking,alcohol consumption,history of hypertension,history of diabetes mellitus,whether combined with intestinal chemosis and celiac disease had no significant effect on serum PGⅠ,PGⅡ,PGR and G-17 levels(P>0.05).Conclusion(1)The levels of serum PGⅠ,G-17 and PGR are correlated with Hp infection and gender.(2)When gastric mucosa atrophy and ulcer occur,the levels of PGⅠ,G-17 and PGR will have corresponding changes.They can reflect the lesion degree of gastric mucosa to a certain extent.(3)The levels of PGⅠ,G-17 and PGR showed higher diagnostic efficacy for gastric atypical hyperplasia,and the combined diagnosis was better.