| Objective:To seek a more suitable bowel preparation protocol for pediatric patients by comparing the intestinal preparation adequacy rate,adverse effects,and lesion detection rate of different doses of compound polyethylene glycol electrolyte dispersion for bowel preparation prior to pediatric colonoscopy,in order to provide a reference for the bowel preparation protocol prior to pediatric colonoscopy.Methode: In this study,128 children who were admitted to hospital from November 2020 to March 2023 for complete colonoscopy were selected using a prospective,randomized controlled trial,and the children were assigned into 64 cases in the small-dose group and 64 cases in the high-dose group using a random number table.The small dose group received 50ml/kg of total dose in 2 doses(at 1900 hours on the day before the gastroscopy and at 0500 hours on the day of the gastroscopy,with the total amount not exceeding 4 L),and the large dose group received 100 ml/kg of total dose in 2 doses(at 1900 hours on the day before the gastroscopy and at 0500 hours on the day of the gastroscopy).Each oral dose of the drug was consumed within 1 hour.On the day of colonoscopy,information about the patient should be collected: name,gender,age,BMI,reason for colonoscopy,bowel movement and adverse reactions during bowel preparation.The quality of bowel preparation was assessed according to the Boston Bowel Preparation Scale(BBPS),and the presence of lesions(e.g.polyps,adenocarcinoma,inflammatory bowel disease,colorectitis,etc.)was recorded.Statistical analysis was performed using SPSS 26.0(SPSS Inc.,Chicago,USA)software.Normality tests were performed using the one-sample Kolmogorov-Smirnov test,and measures conforming to normality were expressed as((?)±SD),and t-tests were used for comparison between the means of two groups.Count data were statistically described using rates,and statistical inference was performed using chi-square test.Statistical analysis was performed by two-sided test,and the significance test level was α=0.05.Results: A total of 128 individuals completed the examination,64 in the small-dose group and 64 in the high-dose group.The results found that: 1)comparison of basic information of the study subjects: gender,age,and reasons for colonoscopy were compared,and there was no statistical difference(P>0.05),and the groups were comparable;2)Comparison of bowel cleanliness BBPS scores: no statistically significant difference in total bowel preparation BBPS scores between the high-dose and low-dose groups(P>0.05),and no statistically significant difference in BBPS scores for each segment of colon preparation(P>0.05);3)Comparison of colonoscopic lesion detection: there was no significant difference in the positive detection rate of endoscopic findings between the two groups(P<0.05);4)Comparison of adverse reactions: Among the adverse reactions in the high-dose group and the low-dose group,the incidence of vomiting and abdominal distension in the low-dose group was significantly smaller than that in the high-dose group,and the difference was statistically significant(P<0.05);5)Bowel cleansing in different defecation situations: there was no significant difference between children with adequate bowel preparation and children with inadequate bowel preparation in the high-dose group(P<0.05),and the difference was not statistically significant;the rate of inadequate bowel preparation was higher in children with constipation in the small-dose group,and the difference was statistically significant(P<0.05).Conclusion: 1)In the two groups of gastrointestinal preparation protocol,the quality of intestinal preparation was comparable in the low-dose group compared with the high-dose group,and the lesion detection rate was comparable in both groups,while the incidence of adverse reactions was lower in the subjects of the low-dose group,so the low-dose group is worth promoting in clinical practice.2)For children with constipation,the high-dose compound polyethylene glycol electrolyte dispersion has a better cleansing effect. |
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