Epidemiological Characteristics Of Hyperuricaemia In Mongolian Adult Populations And Mendelian Randomization Study Of Its Related Factors

Objective:To attain the epidemiological characteristics and relevant factors of hyperuricaemia（HUA）in mongolian adult populations through data from field epidemiological study conducted in Inner Mongolia Autonomous Region from 2018 to 2020was analyzed and further explore the risk factors of HUA in mongolian adult populations by combining the former with Mendelian randomization study to lay the theoretical and scientific basis for control and prevention of HUA and development of public health strategy and measures related to HUA in mongolian adult populations in Inner Mongolia Autonomous Region.Methods:Multi-stage stratified and probability proportional to size cluster random sampling methods were adopted;2525 mongolian persons with the age over 18-year-old were sampled in Inner Mongolia Autonomous Region from August 2018 to August 2020 and we collected the data including subject demographics（age,gender,educational level,marital status and occupation and so on）,personal history（smoking,drinking,activity and the such）and dietary status;we performed the physical examination（height,body weight,waist circumference,hip circumference and blood pressure and the such）and blood chemistry including uric acid,triglycerides,high density lipoprotein cholesterol,low density lipoprotein cholesterol and total cholesterol and so forth.Prevalence rate of HUA was statistically analyzed and analysis of risk factors was made by logistic regression analysis and decision tree model.In the first,we regard the HUA-related factors as the exposure and the uric acid as outcomes and two-sample Mendelian randomization analysis was made based on the data from genome-wide association study concerning European populations;then,the variable possibly bearing a cause and effect relationship to the outcomes in the Mendelian study was further analyzed by multivariate Mendelian randomization analysis to determine the independent influence of the variables on the outcomes.Results:（1）2219 valid samples in total were included in our study;prevalence rate of HUA in mongolian adult populations was19.74%and standardized prevalence rate was 21.07%;there were 835 male cases and 1361female cases in our study and the prevalence rate in male populations（26.3%）was higher than that in female populations（15.6%）,the difference between the prevalence rates in the different populations divided according to heights,body weights,occupations,educational levels and places of residence showed statistical significance（P<0.05）.（2）Logistic regression analysis results showed that the incidence of HUA had a positive correlation with the overweight/obesity（OR=2.002,95%CI 1.519～2.638）,dyslipidemia（OR=1.620,95%CI1.271～2.064）,abnormal blood sugar（OR=1.563,95%CI 1.95～2.046）,pork consumption（OR=1.231,95%CI 1.139～1.330）,mutton consumption（OR=1.287,95%CI 1.179～1.404）,poultry meat consumption（OR=1.111,95%CI 1.024～1.206）and alcohol use（OR=1.145,95%CI 1.008～1.302）.And it had a negative correlation with the female（OR=0.641,95%CI 0.498～0.827）,physical working（OR=0.629,95%CI 0.477～0.829）,legume plants and its products consumption（OR=0.889,95%CI 0.811～0.976）and milk and milk products consumption（OR=0.854,95%CI0.785～0.921）.（3）Decision tree model results showed that:pork consumption,overweight/obesity,dyslipidemia,mutton consumption and gender were influencing factors of HUA.（4）Based on the summary statistics from the large-scale genome-wide association study,two-sample Mendelian randomization study results showed that:the increase in the body mass index,the triglycerides level and the pork consumption and the decrease in the high-density lipoprotein cholesterol can lead to the increase in the uric acid.（5）With other three factors unchanged,multivariate Mendelian randomization study results showed that the causality between the three factors including BMI（b=0.246,P=8.89×10-⁹）,HDL（b=-0.074,P=0.046）and TG(b=0.145,P=7.32×10^-5)and UA still held,while causality between pork consumption and UA showed no statistical significance（b=-0.074,P=0.096）.Conclusion:The prevalence rate of HUA in mongolian adult populations in Inner Mongolia Autonomous Region was relatively high;it had a correlation with gender,occupation,BMI,blood lipid level and part of dietary factors and the causality between the three factors（including BMI,TG and pork consumption）and UA was found.The above findings were related to the factors including lifestyle and food culture and so on of mongolian adult populations.