Effect Of Escitalopram Oxalate Combined With Idebenone On Cognitive Function In Patients With Depressive Disorder

Objective:This study aims to explore the clinical efficacy of Idebenone on cognitive function of patients with MDD and its association with depressive symptom,activity of daily living and treatment emergent symptom.Based on the results of this study,we could furtherly clarify the therapeutic value of Idebenone on cognitive impairment of MDD patients and its possible mechanism of treatment efficacy,and provide scientific basis for constructing consummate program of clinical diagnosis and treatment and improving prognosis for MDD.Methods:60 inpatients with depressive disorder accompanied by cognitive impairment from January 2018 to November 2018 in Linyi Mental Health Center of Shandong province were selected by convenience sampling method,the patients were randomly divided into study group(N = 30)and control group(N = 30).The patients in the study group were treated with oxalate and escitalopram,while the patients in the control group were treated with idebenone,the control group received escitalopram oxalate combined with placebo,mini-mental State Examination(MMSE),Montreal Cognitive Assessment-Beijing Version(Moca),Hamilton Depression Scale(Hamd),Activity of Daily Living Scale(ADL)and Treatment Emergent Symptom Scale(Tess)were measured.Results: There were no significant differences of gender and age between the study group and the control group(P>0.05).The scores of MMSE and Mo CA in the two groups were compared at 2 weeks,4 weeks,6 weeks,8 weeks and 12 weeks,The results indicated that only the MMSE score at the end of 8 and 12 weeks of treatment had a statistically significant difference(P < 0.05).Scores of HAMD,ADL and TESS of the study and control groups were compared at 2 weeks,4 weeks,6 weeks,8 weeks and 12 weeks,The results suggested that only the ADL score was statistically significant at the end of 12 weeks of treatment(P < 0.05),while the TESS score was statistically significant at the end of 2 weeks of treatment between the two groups(P < 0.05).Pearson correlation analysis showed that scores of MMSE negatively correlated with HAMD and TESS scores(r=-0.618,-0.429;P< 0.05,0.01),and positively correlated with ADL scores(r=0.539,P<0.01),and score of Mo CA negatively correlated with HAMD(r=-0.318,P<0.05).Multiple regression analysis for associated factors which affecting cognitive function in the study group showed that HAMD had significant predictive effect on scores of MMSE and Mo CA(P<0.05 or 0.01),which could respectively explain38.20%,14.50% of the variance variations.Conclusions:(1)escitalopram combined with oxalate can improve the cognitive function and improve the prognosis of patients with depression.(2)Aidit may play a role in the treatment of cognitive dysfunction in patients with depression by improving the therapeutic effect,improving the ability of daily living and reducing the adverse reactions.