Analysis Of Ocular Biological Parameters And Refractive Error In Myopic Children Of School Age 6 To 12 Years

Objective:To compare the changes in refraction and biological parameters before and after pupil dilatation in school-age children aged 6 to 12 years,to analyze the relationship between age,degree of myopia and biological parameters of the eye,and to assess the role of biological parameters in monitoring the development of myopia.Methods:Prospective study.Eighty-one school-aged myopic children(157 eyes)aged 6 to 12 years attending the Strabismus and Pediatric Ophthalmology Clinic of Shanxi Provincial Eye Hospital from June 2021 to June 2022 were enrolled,and all children were subjected to computerized optometry using a Topcon RM-8000 A optometer before and after dilatation with 0.5% compound tropicamide eye drops(Medolite),application of Lenstar LS900 for Biological measurements were recorded for sphere(DS),cylinder(DC),spherical equivalence(SE),axial length(AL),average corneal curvature(K),axial length/corneal radius of curvature ratio(AL/CR),lens thickness(LT),anterior chamber depth(ACD),and central corneal depth(CCT).Children were divided into mild myopia group and moderate to high myopia group according to post-dilated SE.SPSS 26.0statistical software was used to analyze the data.Results:1.After pupil dilatation,both DS and SE decreased and DC increased compared with those before pupil dilatation,and the differences were statistically significant(P <0.05).After pupil dilatation,ACD and CCT were significantly larger and LT was significantly smaller than before pupil dilatation,with statistically significant differences(P < 0.05),while the differences between AL,K and AL/CR before and after pupil dilatation were not statistically significant(P > 0.05).2.SE,AL,K,AL/CR,LT,and ACD were statistically significantly different between age groups after dilated pupils in school-age myopic children(P < 0.05),while CCT was not statistically significantly different(P > 0.05).3.AL,K and AL/CR were higher in the mild myopia group than in the low myopia group after dilated pupils in school-age myopic children(P < 0.05),and there was a negative correlation between SE and AL and AL/CR for different degrees of myopia,and the correlation between SE and AL and AL/CR was significantly higher in moderate to high myopia(r =-0.751,P < 0.05;r =-0.800,P < 0.05)than in low myopia(r=-0.443,P<0.05;r=-0.528,P<0.05).Correlation of SE with AL and AL/CR increases with age4.Multiple regression model analysis showed that AL and AL/CR had the strongest correlation with SE and there was a linear regression relationship.Conclusion:In summary,refraction,axial length,corneal curvature,axial ratio,lens thickness,and anterior chamber depth change as children grow and develop,with axial length and axial ratio being the main factors affecting refraction in school-age children,and dilated pupils do not affect them.The axial diameter ratio has clinical significance in the mass screening of myopia in children and in the dynamic detection of myopia development,but it does not completely replace astigmatism in the diagnosis of myopia.