The Relation Between Triglyceride-Glucose Index And Uric Acid With In-Stent Restenosis After Percutaneous Coronary Intervention

Objective:We investigated the correlation between triglyceride-glucose index(TyG),uric acid(UA)and in-stent restenosis(ISR)after percutaneous coronary intervention in coronary artery disease patients,and analyze its predictive value for ISR.Methods:The study belongs to a retrospective study.The study analyzed patients with coronary artery disease who implanted drug-eluting stent(DES)for the first time in the Second hospital of Shanxi Medical University.Serum levels of triglycerides(TG),fasting blood glucose(FBG),uric acid(UA),other biochemical parameters and clinical characteristics were measured in 76 ISR patients and 335 non-ISR patients.Meanwhile,To compare the risk assessment efficacy for the formation of collateralization between the TyG index,uric acid,and other metabolic abnormality indicators,multivariate logistic regression analysis models were also constructed.Furthermore,The cut-off values and diagnostic efficiency of the parameters that TyG and uric acid were achieved by receiver-operating characteristic(ROC)curve(AUC).Results:1.The general data of 76 patients in ISR group and 335 patients in Non-ISR group were analyzed.There were no statistical differences in age,smoking and cardiac function between ISR group and NISR group(P > 0.05),There were critic differences in gender,hypertension and diabetes between ISR group and NISR group,and the prevalence of hypertension and diabetes in ISR group was significantly higher than that in NISR group(P < 0.05).2.Compared with the NISR group,the differences of TC,TG,FBG,TyG,UA and LDL-C in ISR group were statistically significant(P < 0.05),and the UA and TyG in ISR group were significantly higher than those in NISR group(UA:3 43.1(295.18,423.80)vs.TyG: 322.9(274.7,369.7),2.07(1.65,2.45)vs.1.66(1.33,1.94))(P < 0.05).There was no significant difference in ALB,Hcy,MPO and FIB between the two groups(P > 0.05).3.The area under of the ROC for TyG,UA,and TyG combined with UA in diagnosing the prevalence of ISR was 0.725,0.586,0.731(95%CI:0.662-0.789,95%CI:0.512-0.659,95%CI:0.668-0.794,P < 0.05).The TyG cut-off value was 2.022 at the maximum of the Youden index,which had the best diagnostic value for ISR with a sensitivity of 56.6%and a specificity of 79.7%.When UA > 347.9μmol/L,it had 47.4 % sensitivity and 69.6%specificity.The AUC was 0.731 with the combined prediction model of the TyG and UA,which had similar predictive value to TyG alone.4.Regression analysis showed that there was no correlation between TyG and UA,and there was no significantly difference(P>0.05).TyG was associated with TC,LDL-C,FIB and diabetes,among which diabetes,LDL-C were positively associated with the TyG(correlation coefficients were 0.581 and 0.188,respectively),and the differences were statistically significant(P<0.05).5.Binary Logistic regression analysis: after adjusting the factors of smoking,hypertension,diabetes,and other biochemical parameters,TyG,UA,and the combined indicators had a significant positive correlation with ISR(P < 0.05).In addition,TyG and UA were independent risk factors for the presence of ISR,after fully adjusting for the potential confounding factors.Conclusion:This study confirmed that TyG and UA were correlated with ISR and were independent risk factors for ISR.