Preliminary Study On Biological Characteristics Of Endometrial Polyps

Part I: Expression of estrogen receptor,progesterone receptor,androgen receptor,vascular endothelial growth factor and P63 in endometrial polyps Objective:The expressions of estrogen receptor,progesterone receptor,androgen receptor,vascular endothelial growth factor(VEGF)and P63 in endometrial polyps were detected by immunohistochemical method,which provided theoretical basis for the treatment and prevention of recurrence of endometrial polyps.Methods:From April,2021 to October,2022,50 patients with abnormal uterine bleeding who underwent hysteroscopic endometrial polypectomy and were diagnosed as endometrial polyps by histopathological examination were collected.The endometrial polyp tissue of the same patient was taken as the polyp group,and the endometrial tissue adjacent to the polyp was taken as the parapolyp group.The expressions of estrogen receptor,progesterone receptor,androgen receptor,vascular endothelial growth factor and P63 in the two groups were detected by reinterpretation and immunohistochemistry,and the expressions of each index in the two groups were processed by SPSS data analysis software and the correlation was analyzed.Results:The expression rate of estrogen receptor and VEGF in endometrial polyp group was higher than that in endometrial parapolyp group(P < 0.05).The expression rate of progesterone receptor and androgen receptor in endometrial polyp group was lower than that in endometrial polyp group(P < 0.05).There was no significant correlation between VEGF and the expression of estrogen receptor,progesterone receptor and androgen receptor in endometrial polyps(P > 0.05).P63 was not expressed in endometrial polyps and endometrial tissues adjacent to polyps.Conclusion:Estrogen receptor and VEGF are highly expressed in endometrial polyps,while progesterone receptor and androgen receptor are low expressed in endometrial polyps,suggesting that the occurrence of endometrial polyps is related to the imbalance expression of sex steroid hormone receptor and VEGF.Part II: Exploring the risk of malignant transformation of endometrial polyps Objective:By analyzing the results of endometrial ultrasound images and related risk factors of endometrial carcinoma in cases with atypical hyperplasia,atypical hyperplasia and endometrial cancer diagnosed by pathology,this paper discusses the malignant transformation risk of endometrial polyps and provides new evidence for screening indexes of endometrial cancer.Methods:From January,2017 to December,2022,420 patients were admitted to hospital for hysteroscopic endometrial polypectomy or diagnostic curettage due to abnormal uterine bleeding,postmenopausal bleeding and other related symptoms,and were diagnosed as atypical endometrial hyperplasia,atypical endometrial hyperplasia and endometrial cancer by pathological examination.Divided into endometrial atypical hyperplasia group,endometrial atypical hyperplasia group and endometrial carcinoma group,the differences of endometrial polyps in the three groups were analyzed to probe into the malignant transformation risk of endometrial polyps.Results:Endometrial polyps and endometrial thickening indicated by transvaginal ultrasound are risk factors for endometrial cancer and atypical hyperplasia,but they are not independent risk factors.Vaginal ultrasound showed that uneven endometrial blood flow signal and endometrial echo,age and postmenopausal status were independent high risk factors for endometrial cancer and atypical hyperplasia.Conclusion:Endometrial polyp is a risk factor for endometrial cancer and atypical hyperplasia.Although it is not an independent high-risk factor,we should pay enough attention when combined with other high risk factors of endometrial cancer.