Examining Risk Variables That Have An Impact On The Pathological Stage And Grade Of Renal Clear Cell Carcinoma

Objective:In order to investigate the molecular mechanisms of risk factors connected to clear cell renal cell carcinoma（ccRCC）and provide a theoretical foundation for the clinical medical and surgical treatment of ccRCC,the goal of this paper is to analyze the effects of risk factors like hypertension,diabetes,obesity,hyperlipidemia,and smoking on the pathological staging and grading of ccRCC.Methods:In this study,707 patients who underwent radical or partial nephrectomy and were given a ccRCC diagnosis by the Department of Pathology were chosen for the study.They all met the inclusion and exclusion criteria,and pertinent clinical and pathological data of the patients were collected.Gender,age,tumor site,blood type,body mass index（BMI）,triglyceride（TG）,high-density lipoprotein（HDL）,history of hypertension,history of diabetes mellitus,and smoking history were all considered clinical data.Pathological data for ccRCC comprised staging and grading.A retrospective analysis was used to compare the differences in the clinicopathological characteristics of ccRCC between these two groups after dividing the aforementioned risk variables into groups with and without metabolic syndrome（MS）and smoking and non-smoking.Based on the aforementioned findings,univariate and multifactor logistic regression was used to investigate the relationship between the aforementioned risk variables and the pathological staging and grading of ccRCC as well as the influence of MS components on these factors.Using SPSS 26.0,all data were statistically evaluated.The measurement data were reported as（?）s,and P<0.05 was considered statistically significant.The t-test was used to compare the means of the groups,the（?）^（17）test to compare counts,and logistic regression analysis to analyze correlations.Results:When the clinicopathological parameters of ccRCC were compared between the MS and non-MS groups using a t-test,the findings revealed that age was the only factor with statistical significance（P<0.05）,while age was not significant in the smoking and non-smoking groups.According to the chi-square test,the gender composition between the smoking and non-smoking groups differed statistically（P<0.001）,although the gender composition between the MS and non-MS groups did not（P>0.05）.Tumor side,location,and blood group differences between MS and non-MS groups and smoking and non-smoking groups were not statistically significant,P>0.05 when clinicopathological characteristics were compared.When comparing the clinicopathological traits of the MS and non-MS groups,the differences in hypertension,Diabetes mellitus,obesity,and hyperlipidemia were statistically significant（P<0.001）.The differences between MS and ccRCC staging and grading were statistically significant,with P<0.001.The differences between smoking and ccRCC staging were statistically significant（P=0.039）and not statistically significant with ccRCC grading（P=0.075）.There was a statistically significant effect of hypertension,diabetes,hyperlipidemia,and obesity in the MS group on the pathological stage and grading of ccRCC,P<0.001.The results of Logistics regression analysis of ccRCC staging:smoking and metabolic syndrome components were positively correlated for ccRCC pathological staging,P<0.05,and the regression coefficients were>0.Hypertension,hyperlipidemia,and diabetes mellitus in the metabolic syndrome component were independent risk factors for ccRCC staging,P<0.001,and the partial regression coefficients were>0.The corresponding ORs were 12.391,3.659,and 3.685,respectively.The corresponding OR values were 12.391,3.659,and 3.685,respectively,so patients with hypertension,hyperlipidemia,and diabetes increased the ccRCC stage,and those with hypertension increased the ccRCC stage by 12.391 times,those with hyperlipidemia increased the ccRCC stage by 3.659 times,and those with diabetes increased the ccRCC stage by3.685 times.Smoking and obesity were not independent risk factors for ccRCC staging.The results of Logistics regression analysis of ccRCC grading:hypertension, diabetes,obesity,and hyperlipidemia in the MS component were positively associated with ccRCC grading,P<0.05,and their corresponding partial regression coefficients were all>0.In the MS component,hypertension,obesity,and hyperlipidemia were independent risk factors for ccRCC grading,P<0.05,and their corresponding partial regression coefficients were all>0.Therefore,the presence of Patients with hypertension,obesity,and hyperlipidemia affected ccRCC grading,increasing ccRCC grading by 4.23-fold,1.708-fold,and 1.572-fold,respectively.Conclusion:1.The pathological stage of ccRCC is elevated in MS patients with"three highs"and is influenced by variables such as hypertension,hyperlipidemia,and diabetes mellitus that are independent of one another.2.The ccRCC grading was affected by independent risk factors such as hypertension,obesity,and hyperlipidemia and increased in MS patients without diabetes mellitus.3.Smoking affects the pathological stage of ccRCC but is not a risk factor in and of itself.