The Effect Of Intermittent Fasting On Glucolipid Metabolism And Insulin Resistance In Patients With Metabolic Syndrome:A Meta-analysis Of Randomized Controlled Trials

Objective:Whether intermittent fasting can improve glucolipid metabolism and insulin resistance in patients with metabolic syndrome remains unclear.This study systematically reviewed the relevant clinical trials to evaluate the effects of intermittent fasting diet on glucose and lipid metabolism and insulin sensitivity in metabolic syndrome population.Methods:A systematic search of Pub Med a document retrieval and query system developed by the National Center for Biotechnology Information(NCBI)under the National Library of Medicine(NLM),Embase,Web of Science,CINAHL Complete and Scopus,China Journal Network(CNKI),China Biomedical Database(CBM),and Wanfang Database was performed up to March 2023,randomized controlled trials comparing the diets of intermittent fasting and continuous calorie restriction to determine the effect on metabolic syndrome population were selected and analyzed using meta-analysis.Primary outcomes included Weight,body mass index(BMI),waist circumference,homeostasis model insulin resistance index(HOMA-IR),fasting plasma glucose(FPG)and fasting plasma insulin(FPI).Ttotal cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL),high-density lipoprotein cholesterol(HDL),meta-analysis using Stata 17 software.Results:Out of 9 eligible RCTs included in the meta-analysis,involving 519 patients with Metabolic Syndrome.Comparisons of changes before and after treatment with IF groups and CR groups revealed that IF groups showed superiority over CR groups in reducing weight[WMD=-1.05kg,95%CI:(-1.96,-0.14)Kg,P<0.05,I~2=0%],BMI[WMD=-0.80kg/m~2,95%CI:(-1.44,-0.16)kg/m~2,P<0.05,I~2=0%].IF groups demonstrated similar effects to CR groups in reducing waist circumference,improving glucose metabolism and regulating lipid metabolism(P>0.05).Conclusion:Intermittent fasting diets as effective as continuous calorie restriction on blood glucose and lipids in metabolic syndrome population and can significantly improve insulin resistance.Compared with calorie restriction diet,it demonstrates similar effects to calorie restriction diet in reducing waist circumference,improving glucose metabolism and regulating lipid metabolism,and shows better characteristics than calorie restriction diet in reducing weight and BMI,which can be considered as an alternative therapy to calorie restriction diet to prevent the development of chronic metabolic diseases.