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Correlation Between Thyroid Dysfunction And Primary Osteoporosis In Women From Peak Bone Mass Formation To Premenopause

Posted on:2024-09-28Degree:MasterType:Thesis
Country:ChinaCandidate:Y J ShiFull Text:PDF
GTID:2544307148975839Subject:Internal medicine
Abstract/Summary:PDF Full Text Request
Objective:To explore whether there is a difference in bone mineral content and bone density between people with a history of thyroid dysfunction after peak bone mass formation and before menopause in women and those without a history of thyroid dysfunction,so as to guide early screening and treatment in clinical work.Methods:Postmenopausal female patients with complete data who visited our hospital from November 2015 to November 2022 were selected and divided into case group(104 cases in hyperthyroidism group,134 cases in hypothyroidism group)and matched control group(88 cases in normal thyroidism group)according to their previous history of thyroid dysfunction.At the time of data collection,thyroid function indexes in the case group had returned to normal for at least 1 year.In addition,in the hyperthyroidism group,according to the time between onset and data collection(<5 years,5-10 years,>10years),the time between the end of treatment and data collection(<5 years,5-10 years,>10 years)were grouped.Serum ALP,P1 NP,β-CTX,25(OH)D,OC,Ca,P,Mg,FT3,FT4 and TSH of the three groups were detected and recorded.Bone mineral content(BMC)and bone mineral density(BMD)of the lumbar spine,left hip and forearm of the three groups were measured.Results:1.Comparison of baseline data of the three groups: there was no significant difference in age,menopausal age,height,FT3,FT4,Ca,P and Mg of the three groups(P>0.05);Compared with the control group and the hypothyroid group,the TSH level in the hyperthyroid group was significantly reduced(P<0.05),and there was no significant difference in TSH between the control group and the hypothyroid group(P>0.05).Compared with the hypothyroid group,the weight of the hyperthyroid group was lower than that of the hypothyroid group,and the difference was statistically significant(P<0.05),and there was no significant difference in weight comparison between the control group and the hypothyroid group(P>0.05).2.Comparison of laboratory indexes of the three groups: compared with the control group and the hypothyroid group,the bone turnover markers β-CTX and OC were increased in the hyperthyroid group(P<0.05),and there were no significant differences in ALP,P1 NP,25(OH)D.Compared with the control group,there were no significant differences in the bone turnover markers ALP,β-CTX,OC,P1 NP,25(OH)D(P>0.05)in the hypothyroid group.3.Results of bone mineral content and bone mineral density in three groups1)Compared with the control group,the BMC of the forearm(P<0.001),BMD of the forearm(P<0.001),the BMC of the lumbar spine(P<0.05)and the BMD of the lumbar spine(P<0.05)were reduced in the hyperthyroid group,and there was no significant difference between the BMC of the left hip and the BMD of the left hip(P>0.05);2)Compared with the control group,the lumbar BMC,lumbar BMD,left hip BMC and left hip BMD were reduced in the hypothyroid group(P<0.05),and there was no significant difference between forearm BMC and forearm BMD(P>0.05);3)Compared with the hypothyroid group,the BMC of the forearm and BMD of the forearm were reduced(P<0.05)in the hyperthyroid group;there was no significant difference in the BMC of the left hip,BMD of the left hip,BMC of the lumbar spine,and BMD of the lumbar spine(P>0.05).4.Compared with patients with a time of onset > 10 years from the time of data collection,BMC and BMD in the forearm,BMC and BMD in the <left hip,BMC and BMD in the left hip,BMC and BMD in the lumbar spine were reduced(P<0.05).5.Group comparison of spacing data collection time at the end of treatment in hyperthyroid group: compared with patients with a data collection time of > 10 years from the end of treatment,BMC and BMD in the forearm,BMC and BMD in the left hip,BMC and BMD in the lumbar spine were reduced(P<0.05)in patients with 5-10 years and <5 years.6.Correlation analysis between onset time,treatment end time,data collection time,bone mineral content,and bone mineral density in hyperthyroidism group: The correlation analysis of the onset time and data collection time(< 5 years,5-10 years,> 10years)in the hyperthyroid group showed that the time of onset and data collection time were positively <correlated with bone mineral content(forearm,left hip,lumbar spine)and bone mineral density(forearm,left hip,lumbar spine),and the difference between the time of onset and data collection time(< 5 years,5-10 years,>10 years)was between the time of onset and data collection at the end of treatment in the hyperthyroid group 10years)showed that the time of distance data collection at the end of treatment was positively correlated with bone mineral content(forearm,left hip,lumbar spine)and bone density(forearm,left hip,lumbar spine),and the difference was statistically significant(P<0.05).That is,the longer the time of onset and the interval between the end of treatment and the longer the data collection time,the bone mineral content and bone density gradually recover,showing an increasing trend.Conclusions:People with thyroid disease after peak bone mass formation to women with premenopausal disease,whether hyperthyroidism or hypothyroidism,have a negative impact on bone mineral content and bone density,which may increase the risk of primary osteoporosis,suggesting that in clinical work,it is necessary to pay attention to the fact that this part of the population should be screened for bone density in the early stage of menopause,and shorten the bone density monitoring cycle,timely prevention and treatment,thereby reducing the risk of osteoporosis,reducing the probability of fracture,and improving the quality of life in later life.
Keywords/Search Tags:Thyroid dysfunction, Postmenopausal women, BMD, BMC, Osteoporisis
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