Analysis Of Gender Differences In Prevalence,Risk Factors And Predictors Of Hyperuricemia In Community

Part Ⅰ Gender difference analysis of prevalence and risk factors of hyperuricemia in communityBackground: The incidence of Hyperuricemia(HUA)increases year by year,and the difference between male and female prevalence rates increases gradually.With the construction of primary medical system in China,the number of patients receiving HUA by primary doctors increases year by year.Investigating the gender differences in the epidemiology and risk factors of HUA in communities helps the grass-roots to establish an effective management model of HUA.Therefore,community-based investigation on HUA prevalence and risk factors is selected.Objective: To investigate the gender differences in the prevalence and risk factors of HUA in this community,so as to provide evidence-based evidence for community management of HUA patients of different genders.Method: A sample of 2369 permanent residents(10%)in Nanzhai Community of Taiyuan City,Shanxi Province was selected by age stratification to analyze the prevalence of HUA in this community.Relevant data were collected through questionnaires,biological indicators and physical examination,and the difference in prevalence of HUA between male and female groups was compared by gender grouping.At the same time,1967 subjects with complete physical examination data(questionnaire,biological indicators and physical examination)were selected to analyze the gender differences in risk factors of HUA using multi-factor logistics regression model.Results:(1)Gender differences in the prevalence rate of HUA: The prevalence rate of HUA in men is 29.71%,which is significantly higher than that of Hua in women(7.65%).The highest prevalence rate of HUA in men is 45-59 years old(33.75%),while that in women is ≥75 years old(10.47%).(2)Gender differences in risk factors of HUA: the increase of Body mass index(BMI)(OR 1.108,95%CI 1.046~1.174)and dyslipidemia(OR 1.703,95%CI 1.208~2.402)will increase the risk of male HUA,while diabetes mellitus(OR 0.528,95%CI 0.316~0.884)will increase.The increased risk of HUA in women is only related to the increase of BMI(OR 1.122,95%CI 1.027~1.225).(3)Gender differences in the correlation between blood lipids and Fasting plasma glucose(FPG)and HUA: The increased risk of male HUA is related to the increase of Triglyceride(TG)(OR 1.225,95%CI 1.012~1.482)and the decrease of FPG(OR 0.792,95% CI 0.676 ~ 0).However,the risk of HUA in women was not statistically significant with blood lipid and FPG.Conclusion: There were significant differences in the prevalence of HUA among different genders.The prevalence of HUA in men was significantly higher than that in women,and the highincidence age group was 45-59 years old.Primary medical staff should focus on health education for this part of the population.In addition,the risk factors of HUA are related to gender.Therefore,attention should be paid to gender differences and individualized management should be given in the management of patients with HUA.Part Ⅱ Analysis of gender differences in the predictive value of obesity index,TyG index and modified index for HUA in communityBackground: Obesity is closely related to HUA.However,BMI is not the only obesity screening index.Studies have shown that Lipid accumulation product(LAP)can better predict the occurrence of HUA.HUA was related to FPG and blood lipid spectrum,while its relationship with blood lipid spectrum was focused on TG.Triglyceride glucose(TyG)index was calculated based on TG and FPG to be a surrogate marker of insulin resistance,while UA increase was related to insulin resistance.Therefore,we designed this study.Objective: To find indicators with higher prediction value for primary medical identification of HUA,and provide prediction indicators for the establishment of primary HUA management model.Method: 631 subjects with complete physical examination data were selected from the community health examination population in Nanzhai,Shanxi Province.Multivariate logistics regression model was used to analyze the relationship between obesity index,TyG index and improved index and HUA in different gender groups.ROC curve was used to evaluate the prediction of obesity index,TyG index and improved index in identifying the risk of HUA,and Z test was used to compare the AUC differences of different indexes.Results:(1)In men,the ability of LAP to identify HUA is significantly higher than that of Waist circumference(WC),Chinese Visceral Adiposity Index(CVAI)of China,TyG index,TyGWC index and TyG-WHt R index.The value of TG in predicting HUA is higher than that of TyG index.(2)In women,the BMI,TyG-BMI,TyG-WC and TyG-WHt R indexes are significantly higher than CVAI in the identification of HUA,and the predictive value of TyG-BMI index for HUA is also significantly higher than that of WC.Conclusion: The indicators for HUA with the strongest discrimination ability in different genders are not the same.We should pay attention to gender differences in the management of HUA,and adopt different indicators for men and women to assess the risks of HUA.