Correlation Between MRI Findings Of Intracranial Tuber And Clinical Features Of Tuberous Sclerosis Complex

Objective:To explore the correlation between MRI findings and clinical features of intracranial nodules in tuberous sclerosis complex,and to guide the clinical manifestations and prognosis of children with intracranial nodules through their characteristics.Methods:A retrospective analysis was performed on 18 children with tuberous sclerosis complex who were hospitalized in Shanxi Children’s Hospital from July 2021 to June 2023.The MRI manifestations of intracranial nodules were described using tuber count and tuber brain ratio.Results:1、11 patients(61.11%)had depigmentation of skin pigment.18 patients(100%)had epilepsy.Among them,3 cases(16.67%)had infantile spasms,14 cases(77.78%)had focal seizures(3 case of unconsciousness,11 cases of conscious disorder),3 cases(16.67%)had comprehensive seizures,and 2cases(11.11%)had epileptic status.Among the 18 children,13(72.22%)had early onset epilepsy,and 5(27.78%)had no early onset epilepsy.Growth retardation was found in 2 cases(11.11%),cardiac rhabdomyoma in 6 cases(33.33%),and renal cyst in 2 case(11.11%).2、Tuber brain proportion was associated with early onset epilepsy(P<0.001).The tuber brain proportion of cortical/subcortical tubers was associated with early onset epilepsy(P=0.003).There was no significant correlation between the number of tubers and early onset epilepsy(P>0.05).3、There was no significant correlation between the number of tubers or tuber brain proportion and the form of seizures(P>0.05).4、There was no significant correlation between the number of tubers or tuber brain proportion and non neurological lesions(P>0.05).Conclusion:As an MRI manifestation,the proportion of intracranial nodules in patients with tuberous sclerosis complex,especially tuber brain proportion,can better predict the epilepsy in tuberous sclerosis complex and provide reference value for early detection of epilepsy.