Correlation Analysis Of Serum N/OFQ And IL-6 Levels And Patients With Chronic Ischaemic Heart Failure

Objective:The aim of the study was to observe the changes of serum nociceptin/orphanin FQ(N/OFQ)and interleukin 6(IL-6)in patients with chronic ischemic heart failure(CIHF),and to investigate their correlation with CIHF.Methods:The data of 120 patients admitted to Department of Cardiology of the Second Hospital of Shanxi Medical University from January 2019 to March 2022 were analyzed retrospectively.The patients were divided into heart failure group(n=60)and non-heart failure group(n=60)as control group.Sixty patients with CIHF were classified into 26 cases of class II,18 cases of class III,and 16 cases of class IV according to the cardiac function classification criteria of the New York Heart Association(NYHA).In the study,after comparing the differences in N/OFQ and IL-6 between the two groups,analyzing the influencing factors of CIHF,comparing the differences in N/OFQ,IL-6,clinical biochemical indices and cardiac function evaluation parameters,receiver operating characteristic(ROC)curves were applied to explore the predictive value of changes in N/OFQ and IL-6 levels on CIHF.Results:N/OFQ,IL-6,N-terminal B-type natriuretic peptide precursor(NT-pro BNP),left atrial anteroposterior diameter(LAD),and left ventricular end-diastolic internal diameter(LVEDD)were higher in the heart failure group than in the control group(P < 0.05),and these indexes were significantly increased in patients with class III and IV compared with class II cardiac function(P < 0.05).Left ventricular ejection fraction(LVEF)was lower in patients with heart failure than in controls(P < 0.05).Logistic regression analysis showed that white blood cell(WBC),neutrophil(NEUT),N/OFQ,and IL-6 were the influencing factors for CIHF.Correlation analysis showed that N/OFQ was positively correlated with IL-6;N/OFQ and IL-6 were positively correlated with WBC,NEUT,NT-pro BNP,LAD,LVEDD,and negatively correlated with LVEF,respectively.The area under the ROC curve for N/OFQ,IL-6,and NT-pro BNP for predicting the occurrence of CIHF was 0.891,0.873 and 0.775,respectively(P < 0.01).Conclusion:Serum levels of N/OFQ and IL-6 are elevated in patients with chronic ischaemic heart failure and have a more important predictive value for CIHF than conventional NT-pro BNP.