Comparative Study Of Measuring Volumes Of Meningiomas With Tada Formula And 3D Reconstruction Methods

Objective:To discuss the accuracy and application value of Tada formula in evaluating the volume of meningioma based on 3D reconstruction technology.Methods:From January 2014 to May 2022,the thick-slice magnetic resonance images of 297 patients with meningiomas treated at the department of Neurosurgery,The 940 th Hospital of the PLA Joint Logistics Support Force(Lanzhou General Hospital of Lanzhou Military Region)were collected.The volumes of the meningiomas were estimated by Tada formula calculation and three-dimensional methods,and the volume measured by three-dimensional method were considered the true volume of the tumor.Form factor,maximum tumor diameter and maximum tumor 2D product were also recorded.Volumes were compared by using descriptive statistics,correlation analysis,and consistency analysis.Results:Among entire samples and concentrated samples,no significant differences were found between volumes obtained by Tada formula calculation and three-dimensional methods(P>0.05),Spearman rank-correlation coefficients were 0.995 and 0.993,and ICC were 0.992 and0.989,respectively.In Bland-Altman plot,most data points lay inside the limit of agreement.In the comparison of morphological subsets,the accuracy of Tada formula in evaluating the volume of meningiomas with higher degree of irregularity was slightly weak.In the comparison of anatomical subsets,the accuracy of Tada formula in evaluating the volume of supratentorial meningiomas was better than that of infratentorial meningiomas.Correlations between form factor and percentage errors of Tada formula were weak(rs=-0.075 and-0.104),Despite a significant correlation between maximum tumor diameter,maximum tumor2 D product and meningioma volume,volumes could vary significantly for a given diameter or2 D product.Conclusions:The volume of meningioma measured by Tada formula has general agreement with the real volume of meningioma,which can accurately evaluate the volume of meningiomas,the Tada formula can be used as a primary measurement method to evaluate the volume of meningioma in clinical practice.When the meningioma is irregular or located in the infratentorial anatomical area,the meningioma volume measured by the Tada formula may have deviation with the tumor actual volume,at this time,the 3D reconstruction method should be considered.The form factor can be used to accurately quantify the regularity of meningiomas,but form factor is not a suitable parameter to predict estimation error,and maximum tumor diameter and maximum tumor 2D product is also not a reliable surrogate for actual meningioma volume.