| Objective:This study intends to objectively evaluate the clinical efficacy of scalp acupuncture combined with "Kai Siguan" in the treatment of post-stroke depression through a clinical randomized controlled trial,so as to provide a evidence for the clinical application and research of scalp acupuncture combined with "Kai Siguan" in the treatment of post-stroke depression.Methods:A total of 72 PSD patients who met the admission criteria in the affiliated Hospital of Gansu University of Chinese Medicine from November 2021 to February 2023 were selected as subjects.Using SPSS27.0 software,they were randomly divided into control group(n = 36)and treatment group(n = 36).All the patient who met the admission criteria received conventional therapy to control the underlying diseases.The treatment group was given scalp acupuncture combined with "Kai Siguan" on the basis of conventional therapy,once a day,continuous acupuncture for 6 days a week,and rest for 1 day.The control group took paroxetine hydrochloride tablets 20 mg at breakfast daily on the basis of conventional therapy,7times a week.Patients in both groups take 7 days as a course of treatment,a total of 4courses of treatment.The Hamilton Depression Scale-24(HAMD-24),Stroke Specific Quality of Life Scale(SS-QOL),Beck Depression Inventory(BDI)and Motor assessment scale(MAS)were scored before treatment,2 weeks after treatment and 4 weeks after treatment.The data were statistically analyzed by SPSS27.0software,and the difference of clinical curative effect between the two groups was compared.Results:1.There was no significant difference in baseline data(sex,age,course of disease,type of stroke)between the two groups(P>0.05).2.There was no significant difference in the score of HAMD-24,SS-QOL,BDI and MAS between the two groups before treatment(P>0.05).3.Correlation analysis:Before treatment,there was a negative correlation between HAMD-24 score and SS-QOL score in 69 patients,which was statistically significant(P<0.05).4.HAMD-24 score:(1)Time main effect,inter-group main effect and time* inter-group interaction effect all have statistical significance in reducing HAMD-24score(P<0.05).(2)(1)Comparison between groups:After 2 and 4 weeks of treatment,The HAMD-24 score of the treatment group was all lower than that of the control group,with statistical difference(P<0.05).(2)Comparison within groups:After 2 and 4 weeks of treatment,The HAMD-24 score were all lower than those before treatment between the two groups,with statistical difference(P<0.05).After 4 weeks of tretment,The HAMD-24 score was all lower than that after 2 weeks of treatment,with statistical difference(P<0.05).5.SS-QOL score:(1)Time main effect and time * inter-group interaction effect all have statistical significance in increasing SS-QOL score(P<0.05).Inter-group main effect haven’t statistical significance in increasing SS-QOL score(P>0.05).(2)(1)Comparison between groups:After 2 weeks of treatment,There was no significant difference in SS-QOL score between the two groups(P>0.05).After 4 weeks of treatment,The SS-QOL score of the treatment group was higher than that of the control group,with statistical difference(P<0.05).(2)Comparison within groups:After 2 and 4 weeks of treatment,The SS-QOL score were all higher than those before treatment between the two groups,with statistical difference(P<0.05).After 4 weeks of tretment,The SS-QOL score was all higher than that after 2 weeks of treatment,with statistical difference(P<0.05).6.BDI score:(1)Time main effect,inter-group main effect and time* inter-group interaction effect all have statistical significance in reducing BDI score(P<0.05).(2)(1)Comparison between groups:After 2 and 4 weeks of treatment,The BDI score of the treatment group was all lower than that of the control group,with statistical difference(P<0.05).(2)Comparison within groups:After 2 and 4weeks of treatment,The BDI score were all lower than those before treatment between the two groups,with statistical difference(P<0.05).After 4 weeks of tretment,The BDI score was all lower than that after 2 weeks of treatment,with statistical difference(P<0.05).7.MAS score:(1)Comparison between groups:After 2 and 4 weeks of treatment,The MAS score of the treatment group was all higher than that of the control group,with statistical difference(P<0.05).(2)Comparison within groups:After 2 and 4 weeks of treatment,The MAS score were all higher than those before treatment,with statistical difference(P<0.05).After 4 weeks of treatment,The MAS score was all higher than that after 2 weeks of treatment,with statistical difference(P<0.05).8.Comparison of clinical efficacy:After 4 weeks of treatment,the total effective rate of the treatment group was 94.12%,which was significantly higher than that of the control group(68.57%).By nonparametric rank sum test,there was significant difference between the two groups(P<0.05).Conclusion:1.Scalp acupuncture combined with "Kai Siguan" can significantly reduce the degree of depression and improve motor function in patients with PSD,and the efficacy and safety are significantly better than paroxetine hydrochloride tablets.2.Scalp acupuncture combined with "Kai Siguan" can significantly improve the quality of life of patients with PSD,but it does not show a significant improvement compared with paroxetine hydrochloride tablets. |
PDF Full Text Request