| Objective.To evaluate the results of multiple independent studies using Meta-analysis software system and literature system with combined Chinese and Western medicine for anterior uveitis as the research topic,mainly to analyze the efficiency,cure rate and recurrence rate of combined Chinese and Western medicine for anterior uveitis,to evaluate the effectiveness and safety of combined Chinese and Western medicine for anterior uveitis,and to provide a more objective and reliable evidence-based medicine for combined Chinese and Western medicine intervention for anterior uveitis The results of this study were presented.Materials and Methods.Computer searches of China Knowledge Network(CNKI),Web of Science,Vipers Chinese Science and Technology Journal Database(VIP),Wan Fang Database(Wan Fang),Cochranelibrary Database,Pub Med Database,and Embase Database were conducted to collect randomized controlled trials(RCTs)related to the combination of Chinese and Western medicine in the treatment of anterior uveitis or available prospective trials(e.g.,cohort studies,etc.),all with a search timeframe from database creation to December 24,2021,in patients with anterior uveitis and interventions such as oral herbal tonics or proprietary Chinese medicine combined with conventional Western medical treatment measures.After independent screening of the literature by 2 evaluators according to inclusion and exclusion criteria,extraction of data and evaluation of the risk of bias of the included studies using the Cochrane systematic evaluation manual,the data were statistically analyzed for clinical efficiency,clinical cure rate and recurrence rate after follow-up using Review Manager 5.3(V.Revman 5.3)software.Results.A total of 2178 cases(eyes)were included in 27 studies,including 1098 cases(eyes)in the study group and 1080 cases(eyes)in the control group.Meta-analysis results showed thatTotal clinical efficiency: OR=4.76,95% CI(3.17-7.14),P<0.00001;clinical efficiency at 15 days follow-up: OR=3.74,95% CI(2.30-6.09),P<0.00001;clinical efficiency at 30 days follow-up: OR=3.92,95% CI(2.66-5.79),P< 0.00001;clinical efficiency at 2 months follow-up: OR=3.50,95% CI(1.82～6.75),P<0.00001.The differences in total clinical efficiency and efficiency at 15 days,30 days and 2 months follow-up between the two groups were statistically significant.Total clinical cure rate: OR=2.56,95% CI(1.87～3.52),P<0.00001;15-day follow-up clinical cure rate: OR=3.38,95% CI(2.28～5.02),P<0.00001;30-day follow-up clinical cure rate: OR=3.01,95% CI(2.26～4.02),P< 0.00001.There were statistically significant differences in the total clinical cure rate and the clinical effective rate at 15 and 30 days of follow-up between the two groups.Total clinical recurrence rate: OR=0.30,95% CI(10.21-0.44),P<0.00001;6-month follow-up clinical recurrence rate: OR=0.33,95% CI(0.17-0.66),P<0.00001;12-month follow-up clinical recurrence rate: OR=0.25,95% CI(0.12-0.51),P<0.00001.The differences in the total clinical recurrence rate and the recurrence rate at6 and 12 months of follow-up were statistically significant between the two groups.Conclusions Based on the results of the 27 included papers,the treatment of anterior uveitis with Chinese herbal medicine combined with Western medicine or single Western medicine was effective and safe without serious adverse effects,but the efficacy of the combined Chinese and Western medicine treatment of anterior uveitis may be better than the conventional Western medicine treatment regimen,and the total recurrence rate after follow-up was also lower in the treatment group than in the control group.The OR values of the total clinical efficiency and the efficiency at 15 days,30 days and 2 months of follow-up for both groups and the total clinical cure rate and the efficiency at 15 days and 30 days of follow-up for both groups were greater than 1,indicating that more events occurred in the treatment group and the efficiency and cure rate were higher than those in the control group.The OR values for the total recurrence rate and the recurrence rate at 6 and 12 months of follow-up were less than1 in both groups,indicating that fewer events occurred in the treatment group and the recurrence rate was lower than that of the control group.The quality of the literature included in this study was uneven,and the interventions were not completely uniform across all the literature treatment groups in this study.The recurrence rate is a very clinically significant outcome indicator for evaluating anterior uveitis,and in some of the literature,patients who underwent combined Chinese and Western medicine treatment for anterior uveitis were not followed up and the recurrence rate of patients was not counted.Because this study was influenced by the quality of the literature,more sample size and high-quality studies are needed to validate this conclusion in the future. |
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