Effect Of Combination Of PPOS Regimen And GH On IVF-ET Treatment Outcomes In Elderly Patients With Low Ovarian Response

Objective:To investigate the effect of progestin primed ovarian stimulation（PPOS）combined with growth hormone（GH）on poor ovarian response.POR)in vitro fertilization and embryo transfer（IVF-ET）.Methods:The patients who were treated in the Department of Reproductive Medicine of Handan Central Hospital from January 2018 to December 2021 were selected.A total of 60 IVF/intracytoplasmic sperm injection（ICSI）cycles were included in this study.According to the use of GH pretreatment,the subjects were divided into study group（30 cases）and control group（30 cases）,all of whom were given PPOS regimen.The general information,ovulation induction,embryo status and clinical pregnancy outcome of the two groups were compared.Results:There was no significant difference in general data between the study group and the control group（all P<0.05）.The days of Gonadotropin（Gn）the total amount of Gn,Human chorionic gonadotropin（HCG）and follicle stimulating hormone（FSH）in the two groups were recorded.FSH level,luteinizing hormone（LH）level on the day of HCG administration,endometrial thickness on the day of HCG administration,number of follicles on the day of HCG administration,P level on the day of HCG administration,number of oocytes retrieved,number of mature oocytes,mature oocytes rate,normal fertilization rate,normal fertilization rate,and cleavage number were compared.The differences were not statistically significant（all P<0.05）.The E₂ level on the day of HCG administration,the number of available embryos and the number of high-quality embryos in the study group were significantly lower than those in the control group（1319.05±635.81vs1012.38±504.61）;2.00（1.00,3.00）vs1.00（1.00,2.00）;1.00（0.00;2.00）vs1.00（0.00,1.00）,differences were statistically significant（all P<0.05）;There were no statistically significant differences in the implantation rate,clinical pregnancy rate,and live birth rate between the study group and the control group（all P>0.05）.Conclusions:For POR patients aged 35-43 years old,GH pretreatment before ovarian stimulation does not increase the final number of oocytes obtained,but increases the E₂ level on HCG day,the number of available embryos and the number of high-quality embryos,so as to further improve the clinical pregnancy outcome of in vitro fertilization（IVF）.However,the specific mechanism and clinical effect still need to be further studied.