Clinical Characteristics Of Incomplete Kawasaki Disease And Coronary Arterial Lesion Risk Factors

Objective(s):To explore the clinical characteristics and risk factors of coronary artery disease in incomplete Kawasaki disease by analyzing the general situation,clinical manifestations,and laboratory indicators of children with Kawasaki disease.Method(s):1.A total of 97 cases of Kawasaki disease that met the inclusion criteria were collected,and 70 cases were divided into complete Kawasaki disease group and 27 cases of incomplete Kawasaki disease according to diagnosis;According to coronary artery lesions,32 cases were divided into coronary artery group and 65 cases in the non-coronary artery group 2.Record the gender and age of the child,use electrochemical method to determine plasma PCT,immunoturbidimetry to determine CRP and ALB,Sysmex XS-8ooi automatic blood analyzer to detect plasma WBC,ANC,PLT,and automatic biochemical analyzer to detect ALT,AST,and TBil.In addition,the absolute and Z values of coronary artery diameter were measured using Doppler echocardiography in the two groups of patients.4.SPSS 26.0 data analysis software was used for data processing and analysis,and a bilateral test(P<0.05)was considered statistically significant.Result(s):(1)A total of 97 cases of Kawasaki disease that met the inclusion criteria were collected,including 70 cases in the complete Kawasaki disease group and 27 cases in the incomplete Kawasaki disease group.(2)General information:There was no statistically significant difference in gender and age between the two groups of children(χ~2=0.483,P=0.487;Z=1.413,P=0.158),but the proportion of deviation from the conventional onset age(<1year old or>5 years old)in the two groups was 12.85%and 40.74%,respectively.The difference between the two groups was statistically significant(χ~2=9.256,P=0.020).(3)Clinical manifestations:the most common in the incomplete Kawasaki disease group was bilateral cervical lymphadenopathy(74.1%),followed by lip and oral changes(63.0%)and non-purulent bulbar conjunctivitis(63.0%).Purulent bulbar conjunctivitis(100%)was the most common in the complete Kawasaki disease group,followed by lip and oral changes(94.3%)and bilateral cervical lymphadenopathy(91.4%).(4)Laboratory results:There was a statistically significant difference in the levels of CRP and PCT between the two groups(Z=2.890,P=0.004;Z=2.680,P=0.007).(5)Coronary artery lesions:There was a statistically significant difference in the incidence of CAL between the two groups(χ~2=6.021,P=0.014).(6)Binary Logistics Attribution Analysis:IKD(OR=2.873,95%CI:1.042～7.922,P=0.041)and age(OR=0.966,95%CI:0.942～0.991,P=0.009)were independent influencing factors of CAL.Conclusion(s):(1)Compared with CKD,the clinical characteristics of IKD are age deviation from the conventional onset age(<1 year old,>5 years old),high incidence of cervical lymph node enlargement,high incidence of CAL,low CRP value,and low PCT value.(2)Low age and IKD are independent risk factors for the occurrence of CAL.