The Relationship Between Serum Uric Acid/creatinine Ratio And Vitamin D In Type 2 Diabetes Mellitus

Objective:To investigate the relationship between serum uric acid/cretinine（SUA/SCr）ratio and vitamin D in patients with 2 diabetes mellitus（T2DM）.Method:A prospective review was executed on 338 patients with treated in the inpatient Department of Endocrinology of Hebei Genernal Hospital between July 2020 and July 2022.Relying to the level of25-hydroxyvitamin D₃（25（OH）D₃）,338 patients in total fulfilled the selection requirements of this study.They were split into two categories:those who did not lack vitamin D（n=121）and those who did（n=217）.Then,with median SUA/SCr as the boundary,diabetic patients were split into high SUA/SCr group and low SUA/SCr group,and subgroup analysis was conducted on the basis of gender and Body mass index（BMI）,which were split into male group and female group,high BMI group and normal BMI group.All clinical data,biochemical parameters and 25（OH）D₃levels regarding diabetic patients were collected and recorded,and SUA/SCr was calculated.Data were statistically analyzed by SPSS25.0 software to analyze the risk factors for the development of vitamin D deficiency in T2DM patients and to calculate the predictive value of SUA/SCr for the development of vitamin D deficiency in T2DM patients.Results:1.Comparison of clinical data on different vitamin D concentration in diabetic patients:compared with patients in the non-vitamin D deficiency group,patients in the vitamin D deficiency group had lower age,duration of diabetes,Alb,and Scr concentrations than those in the non-vitamin D deficiency group,while AST,SUA,GFR,TG,Hb Alc,SUA/SCr were all higher than those in the non-vitamin D deficient group,and the differences were statistically significant.2.Comparison of clinical data on different SUA/SCr concentrations in diabetic patients:BMI,SUA,GFR,and TG concentrations were higher in the high SUA/SCr group than in the low SUA/SCr group,and the differences were statistically significant.In coontrast,age,SCr,and25（OH）D₃concentrations were fewer than those in the SUA/SCr group,and the differences were statistically different.In male T2DM patients,25（OH）D₃concentrations were significantly fewer in the high SUA/SCr group compared with the low SUA/SCr group（P<0.001）.In women with T2DM,the 25（OH）D₃concentrations in T2DM patients were fewer in the high SUA/SCr category than in the low SUA/SCr category,the difference was not significantly different.In T2DM patients with high BMI,25（OH）D₃concentrations were significantly lower in the high SUA/SCr group compared with the low SUA/SCr group（P<0.001）.In T2DM patients with normal BMI,25（OH）D₃concentrations were reduced in the high SUA/SCr group compared with the low SUA/SCr group,but the difference was not statistically significant.In addition,SUA/SCr concentrations were increased in the high BMI group compared to the normal BMI group,but the difference was not statistically significant.3.According to a Spearman correlated study,25（OH）D₃concentrations in T2DM individuals were significantly associated with age,Alb,and Scr,and negatively correlated with FBG,BMI,SUA,GFR,TG,Hb A1C,and SUA/SCr.4.Multiple linear regression analysis showed that SUA/SCr was an independent risk factor for the development of vitamin D deficiency in patients with T2DM（P<0.05）.5.The results of ROC curve showed that the AUC of SUA/SCr was0.669,corresponding to a p value less than 0.05,and SUA/SCr had predictive value for the development of vitamin D deficiency in T2DM patients.the AUC of SUA was 0.624,corresponding to a p value less than0.05,indicating that SUA/SCr was a better predictor of vitamin D deficiency in T2DM patients than SUA alone risk.Conclusions:1.In the high SUA/SCr and low SUA/SCr category,there were notable changes in vitamin D concentration and the prevalence of vitamin D shortage.2.A subset study revealed that males with T2DM had a considerably stronger connection between SUA/SCr and their chance of developing vitamin D shortage than did women.In comparison to the normal BMI category,the high BMI category displayed a considerably stronger association between SUA/SCr and the probability of developing vitamin D shortage.3.SUA/SCr is an independent risk factor for the development of vitamin D deficiency in T2DM patients.4.SUA/SCr has a predictive value for the development of vitamin D deficiency in T2DM patients and is a better predictor than SUA values alone.