Clinical Study Of Community Acquired Pneumonia In Adults With Viral Mixed Infection

Background and PurposeCommunity-acquired pneumonia(CAP)is a disease that is widespread worldwide.It is one of the infectious diseases threatening human health.It is caused by a single or synergistic action of multiple microorganisms.From the epidemic of influenza A virus to the outbreak of the new coronavirus in 2019,with the epidemic of the virus in recent years,the cause of CAP has also undergone great changes.Single bacterial infections are becoming less common,and mixed infections of viruses and other pathogens are becoming more common(such as viral and bacterial mixed infections,viral and viral mixed infections,etc.).With the development of detection technology,the presence of viruses and bacteria is now detected in about 30%-50% of CAP patients.This article mainly studies the comparison of adult CAP with mixed infection of virus and other pathogens and adult CAP with single pathogen infection,so as to explore the clinical characteristics of adult CAP with mixed infection of virus and other pathogens,and provide clinical basis for treatment.MethodsThe clinical data of 112 CAP patients in our hospital from 2016 to 2019 were retrospectively analyzed,and all patients in the group had passed pathogenic testing to confirm their pathogens,and the patients were divided into 4 groups based on the pathogenic results.The single bacterial infection group is A1(n=30 cases),the single virus infection group is A2(n=28 cases),the single atypical pathogen infection group is A3(n=22 cases),and the virus mixed infection group is B Group(n=32 cases).The above four groups of patients were given conventional treatment,rational use of anti-infective drugs,phlegm,fever and so on.All patients were followed up during their hospitalization.Results1.The comparison of general clinical data among the groups showed that there was no statistical difference in age,gender,smoking history,and drinking history among the groups(P>0.05).2.Laboratory examination and comparison of CURB-65 scores of patients in each group showed that blood urea nitrogen(BUN)and serum creatinine(SCr)values were higher in group B compared with groups A1,A2,and A3(P<0.05);The number of CURB-65(2-4points)in group B is more(P<0.05).3 The comparison of clinical symptoms between the groups showed that the number of fever symptoms in group A2 and group B was significantly more than that in groups A1 and A3(P<0.05);group A1 had significantly more patients with dyspnea than group A3(P<0.05).4.Comparison of treatment indicators and clinical outcomes between groups showed that the time to clinical stability(TTCS)in group A1 was 4(3,5)days,TTCS in group A2 was 4(4,6.75)days,and TTCS in group A3 was 6.00(5.00,8.00)days,group B TTCS is 8.00(5.00,10.00)days.It took longer for group B to reach clinical stability(χ2=29.603,P<0.001);the time for body temperature to return to normal in group A1 was 3.00(1.50,4.00)days,group A2 was 3.50(2.00,5.75)days,group A3 was 4.00(3.00,5.25)days,group B was 6.00(5.00,7.00)days,the time of body temperature returning to normal in group B was increased compared with the other three groups(χ2=21.976,P<0.001);the total length of hospital stay in group A1 was11.0(8.8,14.3)days,group A2 was 11.0(8.0,12.0)days,group A3 was 11.0(9.0,13.0)days,and group B was 13.00(11.0,17.8)days.The total length of hospital stay in group B increased compared with the other three groups(χ2=10.997,P=0.012);There was no significant difference in the clinical outcome of the four groups after the rational use of anti-infective drugs,phlegm,fever and other conventional treatments(P>0.05).ConclusionsThe BUN and SCr values of CAP patients with mixed virus infection are higher than those with single pathogen infection,and the number of CURB-65(2-4 points)after disease evaluation is more than that of single pathogen infection.Adults with mixed virus infection after reasonable treatment The time for CAP to reach clinical stability,body temperature recovery time and total hospital stay are longer than those of CAP infected by a single pathogen,but there is no significant difference in fatality rates among the four groups of adult CAP with different causes.To sum up,adult CAP with mixed virus infection is more severe and takes longer to cure than CAP infected by a single pathogen.However,there is no significant difference in clinical outcomes among CAP infected by these different pathogens.