Relationship Between Breast Nodules And Anxiety,Depression And Metabolic Factors In Physical Examination Population

ObjectiveThe occurrence and development of breast cancer is related to anxiety,depression and abnormal metabolic factors.However,as a high-risk factor for breast cancer,whether the occurrence and development of breast nodules are correlated with anxiety,depression and metabolic factors is rarely studied at home and abroad,and the current conclusions are inconsistent.From April 2021 to July 2021,we conducted a study on the relationship between breast nodules and anxiety,depression and metabolic factors in the physical examination population,and explored the correlation between female breast nodules and anxiety,depression and metabolic factors.MethodsBreast ultrasound results and general data(age,menstrual history,height and weight,etc.)of the patients were collected.Metabolic factors(BMI,blood glucose,blood lipids,uric acid,etc.)were collected.Self-rating Anxiety Scale(SAS)and self-rating Depression Scale(SDS)were used to evaluate the level of anxiety and depression.512 cases of breast nodules detected and 680 cases of breast nodules not detected were studied.χ~2 test,two independent samples t test,Spearman correlation analysis and other statistical methods were used to analyze the incidence of breast nodules in this population and its relationship with anxiety and depression,metabolic factors(such as blood lipid,blood glucose,uric acid,BMI).Odds ratio(OR)and 95%confidence interval(CI)were calculated by logistic regression model to analyze the risk factors of breast nodules.Results1.Among 1192 female subjects,512 cases had breast nodules,the detection rate was42.95%.There was significant difference in the detection rate of breast nodules in different age groups(χ~2=46.207,P<0.05),and the detection rate of breast nodules in 40-49 years old(33.79%)was the highest.The detection rate of breast nodules in postmenopausal women was lower than that in pre-menopausal women(24.02%vs 75.98%,P<0.05).2.The SAS scores of patients with breast nodules were higher than those without breast nodules(39.58±6.87 vs 38.19±5.34,P<0.05).The SDS scores of patients with breast nodules were higher than those without breast nodules(39.67±7.35 vs 38.06±5.75,P<0.05).The detection rate of anxiety in patients with breast nodules was higher than that without breast nodules(7.62%vs 2.94%,P<0.05).The detection rate of depression in patients with breast nodules was higher than that without breast nodules(6.45%vs 2.21%,P<0.05).Spearman correlation analysis showed that breast nodules were positively correlated with anxiety and depression(r=0.107,P<0.05;r=0.106,P<0.05).3.The mean fasting blood glucose of patients with breast nodules was lower than that of patients without breast nodules(4.727±0.800 vs 4.846±1.151,P<0.05).The mean value of triglyceride in patients with breast nodules was lower than that without breast nodules(1.206±0.784 vs 1.329±1.058,P<0.05).The mean value of uric acid in patients with breast nodules was lower than that without breast nodules(291.251±65.099 vs 303.014±66.985,P<0.05).The levels of fasting blood glucose,triglyceride and uric acid in patients with breast nodules and those without breast nodules were all within the normal range.4.Multivariate logistic regression analysis of breast nodules showed that age group30-39 was the risk factor for breast nodules(OR:1.514,95%CI:1.047-2.189).Age 40-49 was a risk factor for breast nodules(OR:3.013,95%CI:2.033-4.466).For patients without anxiety,anxiety was a risk factor for breast nodules(OR:1.957,95%CI:1.035-3.701).For those without depression,depression was a risk factor for breast nodules(OR:2.090,95%CI:1.026-4.260).5.There were no significant differences in the classification of BI-RADS,maximum cross-sectional diameter,single or multiple SAS and SDS scores in patients with breast nodules(P>0.05).There were no significant differences in BMI and cholesterol levels between the breast nodule group and the group without breast nodule(P>0.05).ConclusionsThe prevalence of breast nodules is relatively high,and the incidence of breast nodules is related to anxiety and depression.Improving life,regulating mood and relieving life and work pressure may reduce the prevalence of breast nodules.The average levels of blood glucose,triglyceride and uric acid in the breast nodules group were all within the normal range,and the relationship between abnormal metabolic factors and breast nodules was not yet clear.