Analysis Of Risk Factors For Early Recurrence Of Pancreatic Ductal Adenocarcinoma After Pancreatectomy

Objective:To explore the independent risk factors of early recurrence of pancreaticbody and tail duct adenocarcinoma after pancreatectomy,and providereference for clinical diagnosis and treatment.Actively prevent patientswith independent risk factors of early postoperative recurrence,so thatpatients can have better survival benefits.Methods: The data of 71 patients who underwent distal pancreatectomy for pancreatic ductal adenocarcinoma in the Second Affiliated Hospital of Kunming Medical University and the First People’s Hospital of Yunnan Province from October2014 to October 2020 were retrospectively analyzed.The patients were divided into early relapse group and early non relapsegroup according to whether they recurred within 12 months after surgery.The general data of patients,preoperative laboratory and imagingindicators,intraoperative data,postoperative pathological data,postoperative readmission or outpatient return visit information werecollected retrospectively.The clinical data included in the study werestatistically analyzed using SPSS25.0 software,Logistic regression modelwas used to analyze the risk factors influencing the early recurrence ofpancreatic body and tail ductal adenocarcinoma,and to determine theindependent risk factors of early recurrence of pancreatic body and tailductal adenocarcinoma after pancreatectomy.Results:(1)General information of patients: A total of 71 patients who met the inclusion criteria were collected.There were 36 males and 35 females,with an average age of 59.00(50.00,66.00)years(range,36~78 years).Thirty-one patients(43.66%)had early recurrence,and 40 patients(56.34%)had no early recurrence.(2)Logistic univariate regression analysis showed that R0/R1 resection(P=0.016),tumor differentiation(P=0.047),CA199(P=0.017),TNM stage(P=0.011)may be the influencing factors of early recurrence in patients with pancreatic b ody and tail ductal adenocarcinoma undergoing pancreatic body and tail resecti on.(3)Logistic multivariate regression analysis showed that R1 resection(HR =5.421,95% CI: 0.517-56.884,P = 0.029),low tumor differentiation(HR = 10.291,95% CI: 1.060-99.942,P = 0.044),CA199 ≥ 37 ku / L(HR = 0.039,95% CI: 0.951-14.454,P = 3.708),TNM stage(III + IV)(HR = 4.478,95% C I: 0.962-20.836,P = 0.046)were all positive.Risk factors for recurrence of duc tal adenocarcinoma of the body and tail of the pancreas after pancreatectomy.Conclusion: R1 resection,low tumor differentiation,CA199≥37KU/L,and TNM stage are risk factors for early recurrence in patients with pancreatic body and tail ductal adenocarcinoma undergoing pancreatic body and tail resection.