Optimization And Intelligent Control Of Electrical Stimulation In Brain Coupling Network Model

As one of the most common chronic neurological diseases in the world,epilepsy affects millions of People’s Daily life and even threatens their lives.Treatments,surgeries and medications for epilepsy all carry their own risks.Considering the health of patients and the therapeutic effect,electrical stimulation is proposed as a physical intervention to regulate the absence seizure.However,the mechanism of action of deep brain stimulation(DBS)remains unclear.In this study,electromagnetic induction was introduced as a neuroregulatory method to interfere with the firing patterns of pathological neuron activity.First,high frequency(≥100hz)DBS,as a clinically effective means of stimulation,has a remarkable and unimaginable effect in alleviating epileptic motor symptoms.Considering that the regular peaks of standard DBS contribute to the desynchronization of cortical neuronal activity,we hope to explore and combine a new regulatory method that can more effectively reduce the abnormal physiological discharge pattern of the cerebral cortex with the introduction of lower intensity artificial pulses.Secondly,based on the bidirectional coupled corticothalamic-thalamocortical neural cluster model,we studied the effects of DBS and electromagnetic induction,and explored the effects of the separate regulation of DBS and electromagnetic induction and the combined regulation of DBS and electromagnetic induction on the abnormal physiological discharge of the cerebral cortex.By comparison,it can be found that both DBS and electromagnetic induction regulation alone and combined regulation of DBS and electromagnetic induction can induce pathological increased synchronous activity back to normal physiological level,and the combined regulation of DBS and electromagnetic induction has the best effect.In addition,when the intensity of DBS is reduced and electromagnetic induction is introduced at the same time,the benefits are not only more effective in restoring the state of neurons,but also in reducing the energy consumption of DBS to avoid potential damage to tissues or electrodes.Finally,in this work,we applied single-pulse coordinated resetting stimulation(SCRS)to three neurons to investigate the relief and elimination effects of SWDS.Based on the BGCT model of Chen,a simplified 2I:2O cortico-thalamus model was established.Four kinds of m:n on-off SCRS with the same period were compared respectively,and these stimuli were investigated by combining the control efficacy and pulse energy consumption.Considering the uncontrolled side effects of electrical stimulation therapy on brain tissue,we further optimized the regulatory strategy,including the weighted structure of the stimulus and closed-loop control.The weighted stimulus and closed-loop control strategy presented here further improves the control performance by reducing energy consumption,suggesting that it may be more reliable in applications.This study provides a novel method for optimizing SCRS to relieve absence epileptic states through weighted processing of electrical pulses and closed-loop control.This paper explores the effects of DBS combined with electromagnetic induction on improving cerebral cortical dysfunction,especially absence epilepsy.The study further provides a new method for optimizing electrical pulse stimulation,and the results show that the scheme is feasible.