| Objective By analyzing the clinical data of children with abnormal liver function,the causes and related clinical characteristics of abnormal liver function in children were discussed,so as to provide clinical basis for the diagnosis and treatment of children with abnormal liver function.Methods The medical records of 1587 children with abnormal liver function who were admitted to the General Hospital of Ning Xia Medical University from January 2017 to December 2021 were collected and retrospectively analyzed.Results 1.1587 cases of children with abnormal liver function,male 965 cases(60.8 %),female 622 cases(39.2 %),male to female ratio 1.55 : 1.There were 583 cases(36.7 %)in infancy,396 cases(25.0 %)in early childhood,230 cases(14.5 %)in preschool age,304 cases(19.2 %)in school age,and 74 cases(4.6 %)in adolescence.There was no significant gender difference in different age groups(X~2= 6.085,P>0.05).2.According to the etiology of children with abnormal liver function,945 cases(59.5 %)were infectious diseases,539 cases(34.0 %)were non-infectious diseases,and 103 cases(6.5 %)were unknown causes of abnormal liver function.Comprehensive analysis of etiology in children with abnormal liver function,479 cases(30.2 %)of respiratory diseases were the most common,followed by 350 cases(22.1 %)of infectious diseases,211 cases(13.3 %)of drug-induced liver injury,and the proportion of other systemic diseases was relatively small.The distribution of systemic diseases in different age groups was statistically significant(P < 0.05).3.The detection rate of pathogens in 1587 children with abnormal liver function was24.7 %(392 / 1587 cases).Cytomegalovirus infection was the most common,followed by EB virus.The distribution of cytomegalovirus and EB virus in different age groups was statistically significant(P < 0.05).4.Among the different degrees of abnormal liver function in 1587 children,1000 cases(63.0 %)were mild and 512 cases(32.3%)were moderate.Severe 75 cases(4.7 %).There were significant differences in the degree of liver dysfunction among different age groups(P< 0.05).The comparison between groups showed that the degree of abnormal liver function in infancy was lighter than that in infancy(P < 0.005),and the difference was statistically significant.The degree of abnormal liver function in early childhood was heavier than that in school age,and the difference was statistically significant(P < 0.005).The degree of abnormal liver function in different etiology groups was statistically significant(P < 0.05).5.According to the clinical manifestations,201 cases(12.7 %)had specific clinical manifestations,939 cases(59.2 %)had non-specific clinical manifestations,and 447 cases(28.1 %)had no abnormal clinical manifestations.The clinical manifestations of children with abnormal liver function in different age groups were statistically significant(X~2 = 44.436,P < 0.05).The probability of specific clinical manifestations of abnormal liver function in infants was higher than that in preschool age and school age,and the difference was statistically significant(P < 0.005).The clinical manifestations of children with abnormal liver function in different etiology groups were statistically significant(X~2 = 626.488,P <0.05).The clinical manifestations of children with different degrees of liver dysfunction were statistically significant(P < 0.05).The probability of specific clinical manifestations in children with severe liver dysfunction was higher than that in children with mild and moderate liver dysfunction,and the difference was statistically significant(P < 0.0167).6.In terms of disease outcome,the cure rate was 53.6 %,the improvement rate was37.3 %,the unhealed rate was 7.8 %,and the mortality rate was 1.3 %.The therapeutic effect of different etiology groups was statistically significant(P < 0.05).The difference in the therapeutic effect of different degrees of liver dysfunction was statistically significant(P <0.05).The cure rate of children with mild and moderate liver dysfunction was higher than that of severe liver dysfunction,and the difference was statistically significant(P < 0.0167).Conclusion 1.Among the 1587 children with abnormal liver function,abnormal liver function was most common in infancy.2.Infection is the leading cause of abnormal liver function in children,and respiratory infection is the most common.3.The pathogens detected were viruses,bacteria,mycoplasma pneumoniae and fungi.Among the viruses,cytomegalovirus was the most common,followed by EB virus.Brucella is the most common bacteria.4.Most of the children with abnormal liver function are mainly non-specific clinical manifestations caused by primary diseases.Children with specific clinical manifestations such as jaundice and hepatosplenomegaly are relatively common in infants and severe liver dysfunction.5.Abnormal liver function in children is mostly mild,and the clinical cure rate is high after treatment.Only a few children developed acute liver failure. |
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