Clinical Study On The Correlation Between Henoch-Sch(?)nlein Purpura And Caries In Children

Objective To investigate the effect of caries and odontogenic focus infection in children with Henoch-Sch(?)nlein purpura(HSP),clinical controlled trial and oral microbial diversity analysis was applied to preliminarily explore the relationship between dental caries and the development of HSP in children.Methods From September 2021 to September 2022,children with HSP were examined orally at the Department of Pediatrics,General Hospital of Ningxia Medical University.The children were separated into groups based on their caries status and their parents’ willingness to receive oral therapy.The changes in clinical identification and the recurrence of HSP in distinct groups of children with HSP were observed after 3 months of follow-up.Simultaneously,the 16 Sr DNA high-throughput sequencing technique was employed to analyze the composition and alterations of oral microbial types in children with HSP using absolute quantitative sequencing of microbial diversity in saliva and dental plaque of various groups of HSP children.Results 1.A total of 45 children with HSP were enrolled in the study,including 12 cases of HSP caries-free group(group W),18 cases of HSP caries group(group Y),and 15 cases of HSP caries + oral system therapy group(group Z).There was no significant difference in sex or age between the three groups,nor was there a difference in DMFT between group Y and group Z(P > 0.05).2.Three groups of children with HSP were revisited at 3 months:(1)Compared with those at discharge,there was no significant difference in urine routine examination in group W(P > 0.05),and urinary protein(PRO)increased in group Y(P < 0.05).The red blood cell(RBC)and hemoglobin(HGB)levels rose in group Z,whereas the coefficient of variation value of red blood cell distribution width(RDW-CV),monocyte(MONO#)and urinary white blood cell(NWBC)levels declined in group Z.(2)The recurrence rate of HSP was 16.7% in group W,38.9% in group Y and 21.4% in group Z,with no statistically significant difference(P > 0.05).3.The composition of oral microflora in children with HSP was similar across groups,however as compared to children without caries in HSP,the abundance of Prevotellaceae and Streptococcus mutans increased in children with caries in HSP,while oral flora diversity reduced.The diversity of oral bacteria rose significantly after oral systematic therapy.Conclusion 1.Oral assessment and early oral system therapy in children with HSP can help limit the impact of odontogenic lesions on the entire body,lowering the recurrence rate of HSP and the risk of nephritis sequelae.2.On the basis of HSP,caries will further alter the modifications of oral microflora in children with HSP.After oral systemic therapy,the variety of oral microbiota greatly increased.The diversity of oral microbiota in children with HSP is comparable across groups,but compared to those without HSP caries,the abundance of Prevotella and Streptococcus mutans rose in children with HSP caries.