| Purpose: Observe the effects of Zhuluan Decoction on the clinical symptoms,endometrial thickness and type,follicular development and discharge,pregnancy rate,etc.of patients with polycystic ovary syndrome infertility caused by kidney deficiency and blood stasis syndrome.Evaluate the effectiveness of Zhuluan Decoction in treating this disease,and explore effective and safe traditional Chinese and Western medicine for ovulation promotion.Materials and Methods:The 60 patients who met the criteria for intake and excretion were equally divided into two groups.The control group was 30 patients who were given ovulation induction therapy under the regimen of pure western medicine(LE+FSH+HCG),and the test group was 30 patients on the basis of the control group.Help egg soup orally.Observe the two groups of Gn dosage and number of days,endometrial thickness and type,follicle size,follicular development,follicular discharge,LUFS cycle and cancellation cycle,cycle pregnancy rate and pregnancy rate,TCM syndrome score and comprehensive clinical efficacy.Results:1.Gn dosage and number of days: The median number of Gn usage days in the experimental group was 4 days,which was less than 5 days in the control group,and the difference was statistically significant(P<0.05);the median Gn dosage in the experimental group was 300 units,which was smaller than the control There was a significant difference in the group of375 units(P<0.05).2.Cancellation cycles: The number of cancellation cycles in the experimental group was 5(6.0%),which was significantly less than the number of cancellation cycles in the control group,19(22.9%),and there was a significant difference(P<0.05).3.HCG day endometrial thickness and type A rate: 74 cycles in the test group and 52 cycles in the control group.The median endometrial thickness of the experimental group on HCG day was 9.8mm,which was significantly higher than that of the control group,which was8.6mm on HCG day.There was a significant difference(P<0.05);The inner membrane has61 cycles,accounting for 82.4%,which is significantly better than the control group(31cycles,61.5%),and the difference is statistically significant(P<0.05).4.Average diameter of mature follicles on HCG day: The average diameter of mature follicles on HCG day is 19.50 mm,and the average diameter of mature follicles in the control group is 18.50 mm.The average diameter of mature follicles in the test group is higher than that in the control group,with significant difference(P<0.05).5.Follicle development: 84 cycles in the experimental group and 83 cycles in the control group.The experimental group had 2 cycles without follicle development,accounting for2.38%,which was less than the 9 cycles without follicle development in the control group(10.84%),which was significantly different(P<0.05);the experimental group had 68 cycles of single follicular development,Accounting for 80.95%,which is more than 43 cycles(51.81%)of single follicle development in the control group,with significant difference(P<0.05);the experimental group has 9 cycles of multiple follicle development,accounting for 10.71%,which is less than the control group The 19 cycles of multiple follicle development in the group(22.89%)were statistically significant(P<0.05).6.Follicle discharge: 79 cycles in the experimental group and 64 cycles in the control group.The number of normal ovulation cycles in the test group was 73,accounting for 92.41% of the cycles,which was 49(76.56%)higher than the normal ovulation cycles in the control group,which was significantly different(P<0.05);the number of small follicle discharge cycles in the test group was 5.The percentage cycle rate is 6.33%,which is 12(18.75%)less than the number of cycles discharged by small follicles in the control group.There is a significant difference(P<0.05);the number of LUFS cycles in the test group is 1,and the percentage cycle rate is 1.27 %,the number of LUFS cycles in the control group was 3,P>0.05,which was not statistically significant.7.Pregnancy rate and cycle pregnancy rate: The total number of people in the test group and the control group is 30,the number of pregnant women is 12,5,and the pregnancy rates are40% and 16.67%,respectively,there is a significant difference(P<0.05);The number of pregnancy cycles in the test group and the control group were 12 and 5,respectively,and the cycle pregnancy rates were 14.29% and 6.02%,which were not statistically significant(P>0.05).8.Comprehensive clinical efficacy judgment: The TCM symptom product before treatment of the experimental group and the control group were 28.7±2.84 and 29.2±1.86,respectively,with no significant statistical difference(P>0.05),and they were comparable.The TCM symptom scores of the two groups after treatment were 4.00 and 13.00 respectively,P<0.05,with significant differences;the total effective rates of the experimental group and the control group were 90% and 66.67%,respectively,with significant differences(P<0.05).Conclusion1.Zhuluan Decoction can improve the TCM symptom score and clinical efficacy of patients with PCOS ovulation dysfunction infertility due to kidney deficiency and blood stasis.2.Zhuluan Decoction can reduce the dosage and days of use of PCOS ovulation dysfunction infertility with kidney deficiency and blood stasis syndrome Gn.3.Zhuluan Decoction can effectively promote the thickening of the endometrium and optimize the type of endometrium in PCOS ovulation dysfunction infertility with kidney deficiency and blood stasis syndrome.4.Zhuluan Decoction can promote the growth of single dominant follicles in PCOS ovulation dysfunction infertility due to kidney deficiency and blood stasis,reduce the incidence of canceled cycles,increase the ovulation rate,and reduce the ovulation rate of small follicles,thereby increasing the clinical pregnancy rate. |
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