| Objective:The purpose of this study was to explore the distribution characteristics of TCM syndrome elements and coronary artery lesions in patients with CHD and T2DM.The general clinical data of patients in the CHD combined with T2DM group and the CHD group were statistically compared by examining the laboratory indexes,TCM syndrome elements types and coronary artery lesion characteristics.Then the pathogenesis factors between the two groups were analyzed.And to study the difference and relationship between TCM syndrome elements and characteristics of coronary artery disease.It is expected to provide some basis and reference for the clinical prevention and treatment of CHD combined T2DM patients.Methods:According to inclusion and exclusion criteria,a total of 150 patients admitted to the inpatient Department of Cardiovascular Medicine of Beijing University of DongFang Hospital from January to December 2022 were included.There were 80 patients with CHD combined with T2DM and 70 patients with CHD.Basic clinical data of the two groups patients were collected,and laboratory indexes,TCM syndrome elements information and coronary artery lesions were examined to explore the distribution characteristics of TCM syndrome elements in patients with CHD and T2DM and the characteristics of syndrome elements in coronary disease.Results:1.Genetal clinical data:There were no statistically significant differences between patients with CHD combined with T2DM and only CHD in age,sex,BMI smoking,alcohol,consumption,history of dyslipidemia,acute myocardial infarction,arrhythmia,and family history of coronary heart disease(P>0.05).The mean BMI of the total sample was 25.094±3.671,and the mean BMI of 15 patients with coronary heart disease was higher than normal,belonging to the category of overweight(P<0.05).The prevalence of hypertension in CHD combined with T2DM group was higher than that in CHD group,and the difference in prevalence between the two groups was statistically significant(P<0.05).The family history of T2DM was higher in CHD combined with T2DM patients than that in CHD group,and the difference between the two groups was statistically significant(P<0.05).2.Biochemical indicators:The statistical results of this study showed that the differences in blood TG,Urea,Cr,HCY and UA values between CHD combined with T2DM group and CHD group patients were not statistically significant(P>0.05).The mean value of TC in CHD combined T2DM group was 3.29±0.67,the mean value of TC in CHD group was 3.89±0.94,the difference of TC mean between the two groups was statistically significant(P<0.05).The mean value of LDL-C in CHD combined T2DM group was 1.93±0.61,the mean value of LDL-C in CHD group was 2.47±0.85,the difference of LDL-C mean between the two groups was statistically significant(P<0.05).The mean value of HDL-C in CHD combined T2DM group was 1.06±0.26,the mean value of HDL-C in CHD group was 1.22±0.30,the difference of LDL-C mean between the two groups was statistically significant(P<0.05).3.Clinical examination:The results of this study showed that the mean LVEF value of patients in the CHD combined with T2DM group was 0.577±0.124,and the mean LVEF value of patients in the CHD alone group was 0.60±0.088,and the difference in LVEF values was not statistically significant(P>0.05).The number of ST-T abnormalities in CHD combined with T2DM group was 55%,and the number of patients with ST-T abnormalities in CHD alone group accounted for 27.14%,and the ST-T abnormalities in CHD and T2DM group were higher than those in CHD alone,and the difference in ST-T abnormalities between the two groups was statistically significant(P<0.05).Among patients in CHD combined with T2DM group,the number of patients with coronary monobranch lesions accounted for 26.25%,the number of people with coronary bibranch lesions accounted for 27.5%,the number of people with three coronary lesions accounted for the highest proportion was 46.25%,and the number of patients in the simple CHD group with single coronary lesions accounted for 52.86%,the number of people with double coronary lesions accounted for 25.71%,and the number of people with three coronary lesions accounted for 21.43%.Patients in the CHD and T2DM group had a higher probability of coronary multivessel lesions than those in the CHD alone group,indicating that T2DM could increase the risk of coronary multi vessel lesions,and the difference in the number of coronary lesions between the two groups was statistically significant(P<0.05).4.The characteristics of TCM elements in 150 patients with CHD:In this study,a total of 150 patients with CHD were included in the statistical analysis of the TCM elements of CHD patients,which were mainly distributed in Qi deficiency,sputum turbidity,Qi stagnation and blood stasis.The tongue is mainly distributed in:dark tongue.red tongue:Tongue moss distribution in:47 cases of tongue lichen greasy and 44 cases of tongue lichen white;The veins are mainly strings,slippery and sinking pulses.5.TCM elements in patients with CHD combined with T2DM and CHD alone:In this study,the statistical analysis of the distribution of TCM elements in the CHD group alone and CHD combined with T2DM showed that the difference between the two groups was not statistically significant(P>0.05).The difference of Yin deficiency between the two groups was statistically significant(P<0.05),suggesting that patients with coronary heart disease were more likely to have Yin deficiency syndrome when T2DM was combined.Statistical analysis of tongue quality showed that patients in CHD and T2DM group had dark tongue(33 cases)and red tongue(21 cases)as the main manifestations,while patients in the CHD group alone had dark tongue(32 cases)and red tongue(14 cases)as the main manifestations,and the difference in tongue quality between the two groups was not statistically significant(P>0.05).Statistical analysis of tongue moss showed that the tongue moss in the CHD and T2DM group was mainly manifested by greasy moss(26 cases)and white moss(21 cases),while the main manifestations were greasy moss(21 cases)and white moss(23 cases)in the CHD group alone,and the difference in tongue moss between the two groups was not statistically significant(P>0.05).Statistical analysis of pulse showed that the chord pulse(30 cases)and slippery pulse(21 cases)were the main pulse manifestations in the CHD group and the chord pulse(23 cases)and the slip pulse(19 cases)were also the main pulse manifestations in the CHD group alone,and the difference in pulse image between the two groups was not statistically significant(P>0.05).6.TCM elements of diabetic complications:The symptoms of diabetic retinopathy patients are mainly distributed in qi deficiency,yin deficiency and qi stagnation,the tongue is mainly light,dark and red,the tongue moss is mainly yellow,white and less moss,and the veins are mainly string,slip and fine.In this study,in the statistical analysis of TCM evidence in patients with diabetic peripheral neuropathy,it was found that the symptoms of this type of patients were mainly distributed in qi deficiency,qi stagnation,yin deficiency and phlegm,tongue analysis showed that the tongue was dark,light and red as the main tongue manifestations,the tongue moss was yellow,white,greasy,thin and less moss were the main tongue manifestations,and the veins were expressed by string veins and slippery veins.7.The degree of coronary lesions and the characteristics of TCM elements:In this study,the analysis of the characteristics of TCM evidence and the number of coronary artery lesions showed that in the T2DM group of CHD syndrome,patients with qi deficiency(7 cases),yin deficiency(7 cases),Qi stasis(7 cases)and blood stasis(8 cases)were mainly coronary threebranch lesions,Yang deficiency(4 cases)and cold coagulation(1 case)were mainly single branch lesions,and sputum turbidity elements(7 cases)patients were mainly double branch lesions.In the simple CHD group,patients with yin deficiency(2 cases),yang deficiency(9 cases),sputum turbidity(9 cases),cold coagulation(1 case)and Qi stasis(8 cases)were mainly single-branch lesions,Qi deficiency(5 cases)and blood stasis(4 cases)patients were mainly double-branch lesions,while patients with Qi deficiency(4 cases),Qi stasis(5 cases),sputum turbidity(4 cases)and blood stasis(3 cases)also had three lesions.8.The results of binary logistic regression analysis showed that gender,ST-T abnormalities,family history of diabetes mellitus and coronary multivessel lesions were correlated with the incidence of T2DM,and coronary multivessel lesions were associated with qi deficiency,yin deficiency,yang deficiency,sputum turbidity and Qi stasis.Conclusions:1.Combined with T2DM can increase the prevalence of ST-T abnormalities,and coronary multivessel lesions in CHD patients.2.The TCM evidence of CHD combined with T2DM group was mainly qi deficiency,the TCM evidence of simple CHD group was mainly sputum turbidity and Qi stagnation.The combination of T2DM would increase the incidence of negative deficiency in CHD patients.3.The elements of TCM of coronary multivessel lesions in the T2DM group of CHD was mainly distributed in Qi deficiency.Yin deficiency,Qi stasis,sputum turbidity and blood stasis,and the TCM elements of coronary single vessel lesions was distributed in Yang deficiency and cold lectin.In the simple CHD group,the elements of TCM of coronary multi vessel lesions was mainly distributed in qi deficiency and blood stasis,and the elements of TCM of coronary single branch lesions was mainly distributed in yin deficiency,yang deficiency,sputum turbidity,cold coagulation and qi stasis.Coronary multivessel lesions are associated with Qi deficiency,Yin deficiency,Yang deficiency,sputum turbidity and Qi stasis. |
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