Study On The Characteristics Of TCM Syndromes Of Rheumatoid Arthritis Combined With Dyslipidemia And Their Correlation With Disease Activit

Background:Rheumatoid Arthritis(RA)is an unknown systemic autoimmune disease that can occur at any age group,which can cause joint analgesic deformity and loss of function.Multi-system damage such as lesions,anemia,white blood cells and blood cells,peripheral neuropathy,anxiety and depression.Blood lipidomy is one of the common complications of RA.It has a certain correlation with the activity of the disease.The improvement of the indicators can reflect the clinical effect of RA to a certain extent.In addition,abnormal blood lipids can significantly accelerate the occurrence of atherosclerosis,leading to RA patients with abnormal blood lipids,and the risk of cardiovascular disease is significantly higher than that of ordinary people,which greatly increases the mortality rate of patients with RA.In recent years,RA has attracted more and more attention from many scholars of rheumatism,but it is still not very clear about the related mechanism between the two and has limited related research.Western medicine treatment of RA combined with blood lipid abnormalities has long-term poor efficacy,recurrence of diseases,and many adverse drug reactions.Chinese medicine has obvious effects in treating abnormal blood lipids in the treatment of RA,emphasizing overall regulation,dialectical treatment,and individual care,and there are many methods.Such as oral Chinese medicine,acupuncture,massage,ear acupoints,etc.,less adverse reactions are suitable for long-term use.However,the current research on RA combined with blood lipid abnormal syndrome,syndrome distribution,and correlation with disease activity has less research.In order to further tap the prevention and control advantages of the combination of Chinese and Western medicine,the characteristics of the type of traditional Chinese medicine syndrome of blood lipid abnormalities and the characteristics of RA combined with blood lipid abnormalities and the characteristics of the type of traditional Chinese medicine types of blood lipidth The correlation of disease activity is of great significance.Objective:By analyzing and discussing the correlation between the characteristics of the traditional Chinese medicine syndrome type and disease activity of RA merging blood lipid abnormalities,it provides a more objective theoretical basis for the treatment of RA and blood lipid abnormalities in Chinese medicine.Ability,improve the accuracy of syndrome differentiation,improve the quality of life of patients,in order to reduce the risk of cardiovascular disease disease,and can lay the foundation for more in-depth research in the future.Methods:selected RA patients hospitalized at the Department of Rheumatology,Beijing University of Traditional Chinese Medicine from January 2012 to January 2023 as research objects.Ultrasonic.ECG,ultrasonic heartbeat and other information,according to the abnormal blood lipid abnormalities,are divided into RA-blood lipid abnormalities and RA-blood lipids abnormalities.As well as many aspects such as cardiovascular disease risk,analyze and explore the characteristics of traditional Chinese medicine and the correlation with the activity of the disease.Results:1.This study was included in 241 patients with RA,including 54 male patients,187 female patients,and 71.4%of patients with ≥60 years old.Liver and kidney insufficient certificate,damp-heat resistance,accounting for 26.10%,18.30%,and 14.90%of the total,accounting for 59.30%of the entire certificate type.2.The incidence of abnormal blood lipids in this study is 60.58%.① The two groups of patients with RA-Blood Lipidoma and RA-Blood-free abnormalities are generally compared:patients have no statistically significant differences in age,course,gender,smoking history,etc.,but the level of BMI in the RA-Blood Lipidoma Group is higher than that of RA-Bloodless Lipidial Lipida.The differences are statistically significant(P<0.05);in terms of medication:the use rate of RA-blood lipid abnormal group is higher than the RA-blood lipid abnormal group,and the difference is statistically significant(P<0.05),RA-The use rate of hyperlipidex aminotrexate,baocale total glycoside capsules is lower than the RA-Blood-free abnormal group,and the differences are statistically significant(P<0.05);②Disease activity was compared between groups:The joint TJC28 in the RA-dyslipidemia group was greater than that in the RA-dyslipidemia group(P<0.05),and there was no significant difference in SJC28 between the two groups(P>0.05);The level ESR,CRP,and RF levels are higher than the RA-Blood-free abnormal group,and the differences are statistically significant(P<0.05),and the positive anti-CCP positive situation between the two groups,no significant differences in DAS28(ESR)(P>0.05);③Comparison of cardiovascular risk factors in the two groups:The level of the RA-Blood Lipidoma Group HCY is higher than the RA-Blood-free abnormal group,and the differences between the two groups are statistically significant(P<0.05):Learning significance(P>0.05),but in terms of electrocardiogram positive rate.RA-Blood Lipidoma Group Condition(45.9%)is significantly higher than that of RA-Bloody-free abnormal group(29.5%).);The number of RA-Blood Lipid abnormal groups in the active artilorian hardening and left ventricular diastolic function is higher than the RA-Blood-free abnormal group,which is different from statistical significance(P<0.05).There are no differences in large,pulmonary hypertension,and ascending aorta widening(P>0.05);the occurrence of the RA-Blood Lipidoma Group in the occurrence of plaques and the thickening of the middle layer of the cervical arteries is higher than the RA-Bloody-free abnormal group.The difference is statistically significant.(P<0.05).3.In the A-dyslipidemia group,the proportion of sputum and stasis resistance was large,32.2%,and there were no significant differences in the distribution of gender,age,disease course,BMI,RF,anti-CCP and other distribution of different TCM types(P>0.05),but there were statistical differences in the distribution of ESR,CRP and DAS28(ESR)grades between different TCM syndrome types(P<0.05),with the highest levels of ESR and CRP in moist heat resistance,and the DAS28(ESR)grade was dominated by moderate and severe activity.There were significant differences between the distribution of different types and the number of joint tenderness and joint swelling(P<0.05),and the number of joint swelling and joint tenderness were higher due to moist heat paralysis,and there was no significant difference in the distribution of total cholesterol(TC)and tricholesterol yceride(TG)(P>0.05),high-density lipoprotein(HDL-C),There were significant differences in the distribution of low-density lipoprotein(LDL-C)(P<0.05),cardiovascular risk factors between different types:there were no significant differences in homocysteine(Hcy)level,positive ECG and carotid plaque between different types(P>0.05),and there were significant differences in the distribution of endomembrane thickness in the carotid artery(P<0.05).4.The correlation between various indicators and disease activity of RA-Blood Lipidoma Group:ESR and TC,LDL-C are positively correlated(P<0.05),which is not obvious to TG and HDL-C obviously Related(P>0.05);CRP and TC are positive(P<0.05),and there is no obvious correlation with TG,HDL-C,LDL-C.There is no obvious correlation with LDL-C(P>0.05);anti-CCP antibodies are negatively correlated with LDL-C(P<0.05),and there is no obvious correlation with TG,TC,HDL-C(P>0.05);DAS28 It is positively related to LDL-C and TC(P<0.05),negatively related to HDL-C(P<0.05),and no obvious correlation with TG(P>0.05)。Conclusion:1.Blood lipid abnormalities are common complications of patients with RA.This study found that 60.58%of RA patients have varying degrees of blood lipidoma.2.Phlegm and stasis resistance syndrome are the main types of patients with abnormal blood lipids,but the inflammation level of RA patients with abnormal blood lipids with damp-heat jets is higher.3.Compared with the RA-Blood-free abnormal group,the RA-blood lipidoma group patients have higher disease activity and more risk of cardiovascular disease.4.There is a certain correlation between the disease activity and blood lipids of patients with RA patients.