| Objective : There are few epidemiological investigations on nasopharyngeal carcinoma in a province.In order to reflect the epidemiological characteristics of nasopharyngeal carcinoma in our province to a certain extent,establish a reasonable path to select high-risk areas and high-risk groups,and select reasonable screening methods to detect patients,this study is based on the data of hospitalized patients.Summarize the incidence of nasopharyngeal carcinoma in a certain area and provide a basis for preventive measures.Methods: The clinical data of 2499 patients with nasopharyngeal carcinoma diagnosed by pathology in Yunnan Cancer Hospital from January 2013 to December2021 were collected.The incidence trend,region,ethnic distribution,gender and age,family history,first diagnosis symptoms,pathological type,clinical stage,EB virus and EGFR expression were analyzed.Results: The number of patients with nasopharyngeal carcinoma in Yunnan Cancer Hospital remained stable.The largest number of patients in prefecture-level administrative regions was Kunming,Qujing and Zhaotong.The largest number of patients in county-level administrative regions was Xuanwei,followed by Guandu and Xishan.The Han nationality has the largest number of patients,and the Yi nationality has the largest number of patients among ethnic minorities.The ratio of male to female was 2.5 : 1.The average age of onset was 49 years old,and 41-50 years old was the highest age stage.The main clinical manifestations were nasal symptoms and neck symptoms.The pathological type was mainly non-keratinizing carcinoma.The positive rate of EGFR immunohistochemistry was as high as 91.6 %,and the positive rate of EB virus was nearly 60 %.Conclusion: The number of cases of nasopharyngeal carcinoma in Yunnan remained stable and the incidence of different regions in the province was different.The high-risk population was middle-aged and elderly men,and most of them were locally advanced patients.The expression level of EGFR in patients is high,and the positive rate of EB virus is 60 %.The corresponding drugs can be used as soon as possible to suit the patients.At the same time,the knowledge of nasopharyngeal carcinoma should be strengthened in the high-risk areas of the province.Early detection and early treatment.Objective(s):To investigate the efficacy and prognostic factors of nasopharyngeal carcinoma after IMRT in our hospital.Methods: The clinical data of 159 patients with nasopharyngeal carcinoma who were initially treated and treated with IMRT in our hospital from January 2015 to December 2015 were collected.Kaplan-Meier method was used to calculate the survival rate of patients.Log-rank test was used for univariate analysis,and COX regression model was used for multivariate analysis.Results: The median follow-up time was 67 months(7-93 months),the follow-up rate was 89.3 %,17 cases were lost to follow-up,and 32 patients died.The1-year,3-year and 5-year OS of the whole group were 99.3 %,91.7 % and 83.4 %,respectively.LRFS were 98.7 %,91.7 % and 87.3 %,LRCR were 98.7 %,94.3 % and87.3 %,DFS were 92.4 %,79.0 % and 70.7 %,DMFS were 93.0 %,85.4 % and82.2 %.Univariate analysis showed that there were significant differences in the effects of gender and induction chemotherapy on LRFS(P = 0.019,P = 0.036),the effects of concurrent chemotherapy on LRCR(P = 0.037),the effects of age,T and clinical stage on DMFS(P = 0.033,P = 0.011,P = 0.007),and the effects of clinical stage and treatment mode on OS(P = 0.030,P = 0.001).Multivariate analysis :clinical stage(P < 0.05,HR = 0.378,95 % CI : 0.162-0.883)and treatment mode(P< 0.05,HR = 2.973,95 % CI : 1.027-8.607)were independent risk factors for OS.Conclusion(s): IMRT has a significant survival benefit for nasopharyngeal carcinoma,and distant metastasis is the main cause of treatment failure.Treatment mode and clinical stage are risk factors for OS and independent risk factors for OS. |
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