Working Memory Of Plateau Dwellers: Phenomena, Mechanisms And Oxygen Interventio

Objective: Working memory is responsible for the temporary storage and processing of information,and while there is some mechanism of adaptation to the low-pressure,low-oxygen environment in highland sedentary people,there is also evidence that their cognitive brain function is also affected by hypoxic exposure.The purpose of this paper is to explore the physiological mechanisms by which working memory(WM)in sedentary individuals is affected by hypoxic exposure to plateau,and the effect of different oxygen supplementation interventions to improve it.This paper was conducted in a longitudinal intervention control design.Methods: Subjects(selected descent dwellers N=74,M=24.2,SD=1.77),the study was divided into three parts,the first part of the study measured all subjects with blood,questionnaires,and cognitive task tests,and all subjects were grouped by the degree of hypoxia adaptation through K-means cluster analysis of the above indicators,comparing the working memory ability of different groups,and examining the effect of hypoxia The effects of adaptive capacity on working memory in highland sedentary subjects were examined.In the second part of the study,participants were divided into three groups: control,hyperbaric and normobaric oxygen,with hyperbaric and normobaric oxygen being divided into three different intervention time levels of 30,60,and 90 minutes,for a total of 10 sessions every two weeks.The effect of oxygen intervention on working memory in highland sedentary was examined.In the third part,the effect of total bile acids on the modulation of oxygen intervention and working memory was investigated to develop an explanatory mechanism model,controlling for confounding factors such as sleep quality and mental health status.Results:(1)In the first part of the study,the groups differed significantly on the 1back reaction time,with subjects in the superior adaptation group being better than those in the low adaptation group(p=0.051),indicating that those with better adaptation to hypoxia also performed better in the 1back reaction time in the N-back task;(2)In the second part of the study,the hyperbaric oxygen 30-minute group(p=0.022,η2=0.076)and the normobaric oxygen 30-minute group(p=0.010,η2=0.094),differed significantly at the 1-back task response before and after the oxygen intervention,the control group(p=0.004,η2=0.118)and the hyperbaric oxygen 30-minute group(p<0.001,η2=0.252),with significant differences at 2-back task response before and after the oxygen intervention,and the 60-minute normobaric oxygen group(p=0.029,η2=0.069)with significant differences in 2-back task correctness before and after the oxygen intervention.(3)The results of the third part of the study showed that for those with low total bile acids,subjects showed a significant downward trend in working memory capacity as the duration of the oxygen intervention increased(simple slope=0.908,t=2.703,p =0.012);for subjects with high total bile acids,the duration of the oxygen intervention did not significantly predict working memory capacity.Conclusion:(1)Hypoxia adaptation affected the working memory capacity of plateau sedentary;(2)10 sessions of hyperbaric oxygen for 30 minutes,normobaric oxygen for 30 minutes,and normobaric oxygen for60 minutes interventions all contributed to the working memory capacity of plateau sedentary;(3)There were significant differences in the effects of oxygen intervention on subjects with different liver function,and subjects with good liver function(low total bile acids)had better working memory in the hyperbaric oxygen intervention changes were better.Through this study,it was confirmed for the first time that working memory function was also negatively affected by indigenous residents under hypoxic exposure conditions in the plateau,and the corresponding evidence that oxygen intervention can improve this situation was given.It further enriches the theoretical basis in the field of plateau brain science and has application value for the protection of brain health of the world-dwelling plateau people in China.