Cognitive Function Characteristics And Intervention Study Of Meth-dependent Female Adolescents Based On The Cogni Plus System

Research background and purpose:Meth-dependent is a social problem that endangers public safety and can lead to impaired cognitive function in dependent individuals.Adolescents are at a critical stage of growth and development,and methamphetamine impairs them more severely than adults,and cognitive function interventions for adolescents have some social significance.Therefore,this study focuses on the effects of meth-dependent on the cognitive function of female adolescents,and analyzes the intervention effects of the CogniPlus system on the cognitive function of meth-dependent female adolescents.Materials and Methods:Study 1: 60 meth-dependent female adolescents were selected as a meth-dependent group in a women’s compulsory isolation drug rehabilitation facility in Sichuan Province.They were divided into meth-dependent attention group,meth-dependent working memory group,and meth-dependent visual-motor coordination group according to the principle of matching age and education level,with 20 subjects in each group.60 healthy female adolescents were selected as the healthy control group according to the matching principle of demographic factors with the meth-dependent group.The subjects were divided into an attention control group,a working memory control group and a visual-motor coordination control group according to the principle of matching age and education level,with 20 subjects in each group.The cognitive function scores of the meth-dependent group and the healthy control group were collected using the Vienna Test System(VTS).Study 2: 20 meth-dependent female adolescents matched for age and education level were added to the study 1 meth-dependent group as the meth-dependent waiting group,performing cognitive function tests.The meth-dependent group in this study was divided into three intervention groups(meth-dependent attention group,meth-dependent working memory group,and meth-dependent visual-motor coordination group)and a waiting group with a total of 80 participants.6 sessions of cognitive function training(2 times a week,1 time at 2 days interval,20 min each time)were conducted using the CogniPlus system for the meth-dependent intervention group,and no training was conducted for the meth-dependent waiting group.For research ethics,at the end of the intervention training,if the training was effective in the meth-dependent intervention group,the meth-dependent waiting group was given the corresponding training.A follow-up test of cognitive function using VTS was performed on the meth-dependent intervention group one month after the end of the experiment.Result:1.Differences in cognitive function between meth-dependent group and healthy control group:(1)Mean reaction time,dispersion at reaction time,and reaction time parameters were better in the attention control group than in the meth-dependent attention group(t=2.718,2.738,-2.559;all P<0.05).(2)The visual-motor coordination control group had better dispersion angle deviation,time in ideal range than the meth-dependent visual-motor coordination group(t=3.067,-2.148;P<0.05 or P<0.01).2.Differences in cognitive function between the meth-dependent group and the healthy control group after intervention:(1)the dispersion of reaction time was better than that of the meth-dependent waiting group after the intervention in the meth-dependent attention group(t=2.197;P<0.05);the mean reaction time,dispersion of reaction time,and reaction time parameters were better in the meth-dependent attention group on the posttest than on the pretest(t=2.174,3.588,-2.266;P<0.05 or P<0.01).(2)Time in ideal range was better in the meth-dependent visuomotor coordination group than in the meth-dependent waiting group after the intervention(t=2.235;P<0.05);mean angular deviation,dispersion angular deviation,and time in ideal range were better in the meth-dependent visuomotor coordination group than in the pretest after the intervention(t=3.667,3.962,-5.566;P<0.01 or P<0.001).3.Differences in cognitive function between the meth-dependent intervention group tracking and the meth-dependent waiting group: the meth-dependent attention group tracked better mean reaction time and reaction time parameters than the meth-dependent waiting group(t=-2.300,2.372;P<0.05);the meth-dependent visuomotor coordination group tracked better mean angular deviation,distracted angular deviation,and time in ideal range than the meth-dependent waiting group(t=-2.802,-2.963,3.740;P<0.05 or P<0.01 or P<0.001).Conclusion:1.methamphetamine use impairs attention,working memory,and visuomotor coordination in female adolescents.2.By conducting a systematic cognitive training intervention,the cognitive function levels of the meth-dependent attention group and the meth-dependent visuomotor coordination group were better than those of the meth-dependent waiting group,indicating that training based on the CogniPlus system is effective in restoring cognitive function in meth-dependent female adolescents.3.In the one-month follow-up study,it was found that the cognitive function levels of the meth-dependent intervention group were all better than those of the meth-dependent waiting group in the follow-up test,indicating that the effect of the CogniPlus system-based training has some durability.