Studies On Design, Synthesis And Molecular Recognition Of Molecular Tweezer Artificial Receptors Of Steroid Cholic Acid

Molecular recognition is a fundamental characteristic of biochemical systems and plays a central role in biological processes. The study on molecular recognition using the artificial receptors to construct the chemical models or biomimetic systems is one of the challenges in the frontiers of bioorganic chemistry and supramolecular chemistry. Among the variety of artificial receptor models, a special class of receptors called molecular tweezer are currently attracting great interest. In this dissertation, the efforts were focused on design and synthesis of molecular tweezers derived from chenodeoxycholic acid,α–hyodeoxycholic acid and deoxycholic acid and their molecular recognition as well as enantioselective recognition for anions, neutral molecules and chiral molecules. A series of useful, important and creative results have been obtained.Six series of molecular tweezers based on chenodeoxycholic acid,α–hyodeoxycholic acid and deoxycholic acid, including ester-bond type, carbaminate type and unsymmetrical urea, have been designed and synthesized. Fifty five compounds of sixty five molecular tweezers are new compounds. Chenodeoxycholic acid, carbaminate typeα–hyodeoxycholic and deoxycholic acid unsymmetrical urea molecular tweezers were designed and synthesized for the first time. The synthetic methods of the target compounds have been systematically investigated. The...