Studies On Diffusion Behavior And Release Kinetics Of Drug Molecules In Bioerodible Polymer Matrices

Bioerodible, polymeric matrices offer various advantages compared to conventional dosage forms, such as the possibility to control the resulting drug release rates accurately over prolonged periods of time, easiness of administration, good biocompatibility and complete bioerosion (avoiding the removal of empty remnants). So, much more attentions were focused on drug release behavior of bioerodible delivery systems in the past 20 years. But the underlying mechanisms of drug release from bioerodible polymer matrices are very complex as it depends on various factors, such as the interaction between drug and solvent molecules, the diffusion of drug molecules in the polymeric matrices and the degradation of the polymer. This work mainly studied the diffusion of small molecules in the polymer hydrogels and drug release kinetics of bioerodible delivery systems. The main results obtained are:1. A quantitative structure-property relationship (QSPR) study is carried out to develop correlations that relate the structures of organic compounds to their infinite dilution activity coefficients, γ~∞, in water at 25°C, and three...