Preparation And Properties Of Supramole-cular Organogels And Hydrogels

In recent years, supramolecular hydrogels formed by the self-assembly of gelator through intermolecular hydrogen bonding,π-πstacking and other non-covalent bond interations were applied on catalyzer, nanomaterials, drug carriers and other fields because of its properties between the liquids and solids.Several gelators based on L-phenylalanine and a polymeric gelator N-Octadecyl Maleamic Acid (ODMA) were synthesized , the properties of gels and the process of self-assembly were investied. Salicylic acid (SA) release from supramolecular hydrogels and the diffusion mechanism of SA was investigated. The molecular imprinted polymers (MIPs) which prepared by in situ UV photopolymerization of self-assembly molecular gels and then the gelator was washed. The adsorbed difference of D- and L-Phenylalanine on MIPs were investied, respectively. This paper are consisted of several sections as the following:1. The L-phenylalanine-N-carboxyanhydride (L-Phe-NCA) was synthesized from bis(trichloromethyl)carbonate and L-phenylalanine. The average polymerization degree of Octadecyl-L-phenylalanine oligomer is 5 obtained by the ring-open reaction of L-Phe-NCA using octadecylamine as initiator. The morphology and structures of oligomer aggregates in the media were characterized by XRD, FE-SEM and simulated by molecular software.2. Tetraethylammonium 3-{[(2R)-2-(Octadecylamino)-3-phenylpropanoyl]Amino} butyrate (TC18PheBu), a new hydrogelator based on L-Phenylalaine with chirality was synthesized. It can self-assemble in water or different pH buffer solutions and form into superahydrogels . Suprahydrogels were characterized on using FE-SEM , POM, FT-IR, CD and Fluorescene probe.3. Release behavior of drug salicylic acid (SA) released from TC18PheBu LMWG hydrogels is invested.4. The gelator based on N-stearine-N′-steryl-L-Phenylalanine (Bis 18-L-Phe) self-assemble into fibres aggregates through molecular hydrogen bonding and hydrophobic interations in the polymerizable monomer HEMA and crosslinker DPEG200DMA and formed stable gels. The molecular imprinted polymers (MIPs) which prepared by in situ UV photopolymerization of self-assembly molecular gels and then the gelator was washed. The adsorbed difference of D- and L-Phenylalanine on MIPs were investied, respectively.5. The gelator based on N-Octadecyl Maleamic Acid (ODMA) self-assemble into fibres aggregates between molecular hydrogen bonding and hydrophobic interations in the polymerizable monomer HEMA ,MA and crosslinker DPEG200DMA and formed stable supragels. The molecular imprinted polymers (MIPs) which prepared by in situ UV photopolymerization of self-assembly molecular gels and then the imprinted molecular was washed. The adsorbed efficiency difference of D- and L-Phenylalanine on MIPs prepared by different methods, with different templates molecular and different concentration of ODMA were investied , respectively.