The Research For Building Micro-nano Metal/Organic/Biology Advanced Structure On Organic-Supported Surface

Plastics-supported modern material has received increasing attentions because polymers have unique benefits including low cost, easy processability, high transparency, flexibility, light-weight, recyclability and disposability. For example, metal nanoparticles were fabricated on the surface of polymer-supported. Metal nanoparticles have drawn considerable interest in various fields of chemistry, materials, biology and nano-technology because of their unique physical and chemical properties in optical, magnetic catalyse and electronics. In addition, the fabrication of organic/inorganic hybrid materials, and the surface functionalization of polymer-supported. The fabrication of an inorganic oxide layer on organic-supported surface for organic/inorganic compound layers and its surface functionalization has an important theory significance and worthiness. The compound materials have not only the excellent characters of organic polymers, but also the outstanding characteristics of inorganic oxide. That is high and activity reaction, and it is easy to design surface on molecule level. It has found a wide range of applications in colloid self-assembly, packaging, biotechnology, sensors, and opt-electronic devices. However, an important factor restricting the development of the compound material was the low viscidity between organic phase and inorganic phase. Therefore the surface of organic-supported was used to be modified before the compound material fabrication. It was also an important aspect for application that the surface of organic materials was grafted polymer brushes modification in order to the biocompatibility and molecule design for immobilization protein.Base on thinking above, the main contents of this thesis were as follows:1. An approximately monolayer was fabricated on polymer film surface by silanization for assembly golden nanoparticles. The size of particles was about 20 nm. It is easy that golden nanoparticles pattern was gained on the surface by photomask on the process of modification. The effect of pattern was very nice and uniformity on quite bounty area. Owing to the method's catholicity and applicability to all of inert organic surfaces which have similar alkyl C-H structures, meanwhile the existence of the well-established silanes library, it is no doubt that a variety of functional groups hence could be attached onto inert polymer surface for assembly different metal nanoparticles.2.The research of organic/inorganic compound film: (a) The fabrication of BOPP/SiO_x compound film. Here demonstrate a new method, named as "interface-directed sol-gel" is capable of fabricating high quality silicon oxide (SiO_x) film and its patterning onto various commodity plastics. Our method has at least seven advantages than current techniques: simple and fast process at low cost without the need of vacuum devices and cleanroom facilities; mild process without the damage on the substrate because of the exclusion of high-energy species and photolithography; strong interfacial adhesive strength between SiO_x and polymer substrate due to the formation of covalent bond on functionalized surface; easy to obtain clear pattern in large area (cm²) with low line edge variation (<5%) by simple ultrasonic washing or adhesive tape peeling; very smooth SiO_x surface (RMS<9A by AFM) could be obtained by spin-coating; good generality to extend other oxide layer fabrication, for example TiO₂ pattern fabrication shown in this study; versatile functions could be conducted on such SiO_x-coated polymer matrix, as also partially demonstrated by protein immobilization and oxygen barrier test in this study. On the basis of the above merits, we are fully confident that this method would draw a myriad of attentions from academic and industrial fields in that it is highly desirable and important for polymer-supported flexible optical, electrical and biomedical materials, (b) The fabrication of BOPP/SiO_x/TiO₂ compound film: The BOPP/SiO_x/TiO₂ compound film was fabricated by adding a SiO_x transition layer on the process of fabricating BOPP/SiO_x. It was found that the SiO_x has not affected the property of TiO₂. Not destroying the organic-supported, the SiO_x layer can exist stably below TiO₂ layer. The transition layer can play an important role in protecting the organic-supported.3.The research of biocompatibility and surface functionalize about polymer-supported. Monolayer vitriol acid radical or hydroxyl on polymer films (PET,BOPP,CPP) have been synthesized by surface photoreaction modification method using Ammonium persulfate as reagent. The non-specific adsorption has been studied between these films and three kinds of protein (Enzyme, BSA and anti-body IgG). The effect of the surface modification and protein adsorption was determined by Weightiness, FTIR-ATR, Water Contact Angle and fluorescence microscope (Olympus IX-81). As a result, the non-specific adsorption of unmodified and modified PET to three kinds of protein is less. The fewer non-specific adsorption was happen between acidified BOPP and anti-body IgG. It was also appeared between hydroxyl CPP and BSA. Layers of poly (acrylic acid) (PAA), polyacrylamide (PAM) and maleic anhydride (PMAH) have been synthesized on polypropylene (PP) films by a surface photografting modification method using benzophenone (BP) as photoinitiator. Bovine serum albumin (BSA) was subsequently grafted onto these films. The effect of the surface modification and protein adsorption was determined by weight changes, FTIR-ATR, water contact angle measurement s and UV-visible spect-roscopy. The extent of grafting of BSA on the modified PP films decreased in the order PP-g-PMAH > PP-g-PAA > PP-g-PAM.Surface modification through implanting functional groups has been demonstrated to be extremely important to biomedical applications. Here report the potential to perform silanization techniques on alkyl polymer surface, which provide a simple, fast, inexpensive and general method to decorate versatile functional groups at molecular level. As an example, high-density primary amines could be obtained on a model polymer, polypropylene substrate through the reaction between amine-capped silane, 3-aminopropyltriethoxysilane (APTES) and hydroxylated polypropylene surface. A model protein, immunoglobulin (IgG), could be effectively immobilized on the surface after transforming amines to aldehydes by the aldehyde-amine condensation reaction between glutaraldehyde (GA) and amines. The routes we reported here could directly makes use of the benefits from well-developed silane chemistry, and hereby is capable to graft any functionalities on inert alkyl surface via changing the terminal groups in silanes, which should stimuli instantly the development of many realms such as microarrays, immunoassays, biosensors, filtrations, and microseparation.Functionality groups were introduced on the organic/inorganic compound film surface. Make the reaction happen on organic/inorganic compound film surface the same as inorganic-supported surface. Comparing BOPP/SiO_x surface with quartz surface, many characters have the same. The reaction happened on quartz surface had echoed well on organic/inorganic compound film surface. So it can be applied on biochips' area as quartz.