| The MlCs (minimum inhibitory concentrations) of 11 Chinese herbal medicines such asForsythia suspensa (Thunb.), Scutellaria baicalensis Georgi, Carthamus tinctorius L.,, Cnidiummonnieri (L.) Cuss, EPimedium brevicornam Maxim, Angelica sinensis(Oliv). Arnebia euchroma(Royle) Johnst, Gardenia jasminoides Ellis Sophora flavescens Ait. and borax were detected onthe pathogenic bacteria causing endowmetritis in cows in vitro. Enrofloxacin was done the sameas the former. The medicines which had better antibacterial action than the others such asForsythia suspensa (Thunb.), Scutellaria baicalensis Georgi, enrofloxcain etc were selected bythe effect of MICs. According to the Chinese veterinary medicine theories the complexprescreiption gonponqtw was made up of the former medicines. The stabilities, securities, effectsof prevention and treatment cow endometritis at clinic, effects ofgongyanqing on uterus in vitroand in vivo in rabbits and pharmacokinetics ofgongyanqing were studied. The result showed asfoIIowed.Under the condition of 40 f 2 C and 75% of relative humidity the appearantcharacteristcs,PH and the relative condense of gOmpqtw had no notable changes and thecontent of bacicalin was very stable fOr three months, which showed that gongyanqing was notsensitive to the high temperature. On the other hand,when exposed to the 2500LX strong light fOrl5 days,all the characteristics were stable, which showed that the light had no effect ongongyanqlng.The studies of cIinic paramacodynatics showed that when gompqtw and Enrofloxacincombination was applied to treat the endometritis of 69 cows (28 young cows and 41 maturecows), the ratio of cure were l00% for young cows and 9l .30%for mature cows .The effect wasbetter than the enrofloxacin alone (P<0.05). After mature cows were given the combination, thefirst oestrum was 9.6 days ahead and the time between postpartUm and pregnacy was deceded byl 3 days. The ratio of pregnancy in the first oestrum had been increased distinctively (P<0.05). Forthe young cows, the ratio of pregnacy in the first, second and third oestrUm could alI be increaseddistinctively, and the time betWeen postpartUm and pregnacy was deceded by 7.9days.GoMnqing and Enrofloxacin were aPplied respectively to treat the endometritis of 78 cows (21young cows and 57 mature cows). The results showed that goWnqtw could increase the ratio ofpregnacy in the three oestrUm after administration both for young cows and mature cows (P<0.05).The primary administration hed the effects on the oestnJm. The first oestrUm was l3.5 days ahead7Wf*&tez $ff $jhanX#for mature cows and l7.9 days for young cows and the time betWen postPartUIn and l8.5 days formature cows and 34.7 dnys for young cows deceded prmp BOth the prevention and thetreatment groups had the trend to decrease the tAnes of administraion.The results of acute toxic experimeme on mouse were as folIowing: After oral adIninistraion,the LD5, was over l0000mg/kg.b.w and the medmum tolerant dose was l87.5 times. Afterintraperitonea1 injection administraion, the LD5, was 364'3343 ml/kg.b.w The result of skinhypersencitive experiments on caVy showed that gOmpqtw had no hypersencition-Ieadingproperties. The resultS of eyes irrtant experimentS on rabbit showed that gOWqing had thegentle irritant action and this action would disaPpear after fOUrty-eight hours, which showed thatgowtqtw could be given through mucosal administrition.At the fifth minute after giving drug to uterus in vbo of rabbit, the shrinking range was boostup strongly re<0.05) and the shrinking frequency and the activation of uterus were also increased(P<0.0l). The reactions were almost the same as the groups with oxytocin, but gOmpqtw hadmore effectS on the shrinking frequency while the oxytocin had more effects on the shrinkingrange. At the tenth minute, the action ofgOWtw groups had no distinCtive change than thoseat the fifth minute but the oxytocin groups' effectS on s... |
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