Clinical Study Of Farnesol X Receptor And Colorectal Neoplasms

Farnesoid X receptor (FXR) is a super family member of nuclear receptor. Its first discovery was due to the finding that it could be activated by farnesol. However, people now realize that bile acids and their metabolites are the ligands of FXR and their main function in human body is regulating the metabolism and enterohepatic circulation of bile acids.Colorectal cancer (CRC) is the common malignant tumor in our country. Its prevalence in Shanghai has rised to the second rank. There has been a consensus about the correlation between bile acids and the malignant tumor of gastrointestinal tract. The rise of the bile acids concentration has a positive correlation with CRC prevalence. Moreover, bile acids can induce the apoptosis of the colon epithelial cell as well as gene mutation, thus lead to the formation of tumor. Because FXR is the crucial substance to regulate the metabolism and transportation of bile acids, this study aims to investigate the correlation between FXR and CRC.Purpose:Immunohistochemistry method was used to stain CRC tumor tissue and peritumoral normal tissue. When combined with the clinical data, following analysis can reveal the relationship between them.Methods:There are totally132patients enrolled in this investigation. All of them were confirmed CRC by surgical operation and their clinical information are well collected. The immunohistochemistry score of tumor tissue and normal tissue was compared in several aspects such as age, gender, location of the tumor, size, differentiation, shape, depth, invasion and metastasis, staging and survival rate. Statistical methods include independent samples T test, pared samples T test, Kruskal-Wallis test and Pearson Chi-square test. We use SPSS as the analyzing software and p<0.05was regarded as statistically significant.Results:The expression of FXR in tumor is lower than that of the normal tissue (p<0.001). The tumor size is smaller in the group which the tumor FXR expression is obviously reduced from the adjacent normal tissue (p=0.052). The FXR expression is inversely correlated with lymph nodes metastasis (p=0.045). More metastatic nodules were found in the group which the tumor FXR expression is obviously reduced from the adjacent normal tissue (p=0.011). No other significant findings were observed in other aspects.Conclusion:The deletion and decrease of FXR expression in colon and rectum disclose the connection with the development and metastasis of CRC. Its elaborate mechanism remains to be verified by cytological experiments.