| Background:Lower extremity arteriosclerosis obliterans is a high incidence, high disability rate of disease, serious impact on the quality of life of patients. Drugs and surgical treatment have their own limitations. Single drug therapy can relieve clinical symptoms in a certain extent, but can not cure the cause of the disease, so the cure rate is low. Because of the adaptation of the traditional vascular surgical open surgery, most patients can not be treated by surgery. In recent years, endovascular treatment can effectively improve the lower limb blood supply, but the high rate of restenosis after surgery, resulting in lower blood vessel patency rate directly affect the prognosis of patients. At present, it has become an urgent problem to reduce the restenosis after interventional therapy. Traditional Chinese medicine of lower extremity arteriosclerosis obliterans treatment has its own advantages and its mechanism for lowering blood lipid, blood viscosity, antiplatelet, antithrombotic, improve microcirculation, promote the role of the collateral circulation. However, the research on the treatment of restenosis after stenting is rare, Individual reports are based on the treatment of promoting blood circulation and removing blood stasis, and there is no relatively strict randomized controlled study and a clear drug action time target and treatment. Therefore, it is necessary to strengthen the research in this field.In the treatment of ASO, the arterial blood vessels can be treated by endovascular treatment, and the blood supply to the distal limb can be improved, and the clinical symptoms and indexes of patients can be improved. However, the process of atherosclerosis in the primary disease does not stop, because of the continued development of limb arteriosclerosis, resulting in the treatment of the target vessel and its proximal or other parts of restenosis or occlusion. In the long term, the treatment of ASO and the clinical effect of the treatment of supplementing qi and activating blood circulation and disintoxication In order to prevent and treat patients with lower extremity arterial lumen stenosis and occlusion, there are also some clinical effects. Professor Pang crane professor in succession to Professor Chen Shuchang "blood stasis syndrome" based on the idea,he pointed out the main pathogenesis of vascular disease is the "positive deficiency of blood stasis and toxin". He treated ASO with the method of Supplementing Qi and activating blood circulation and removing blood, and obtaining good clinical curative effect for the treatment of lower extremity arterial lumen after operation, modern research shows that the main factors of restenosis after endovascular stent implantation may be the vascular intima hyperplasia and vascular remodeling. A lot of studies have indicated that Chinese herbal medicine can inhibit the proliferation of vascular endothelial cells and vascular remodeling. For example:break stasis drugs can leech extracts can make endothelial cells transmembrane receptor VEGFR2 expression significantly reduced, thereby inhibiting endometrial angiogenesis. In addition, endovascular treatment of the balloon and stent graft after injury to the intima to stimulate the proliferation of vascular intima may be caused by the stent graft, resulting in inflammation and immune response. In recent years, many scholars believe that inflammation caused by arterial intima injury is the primary cause of atherosclerosis, which is the theory of "inflammation-injury-response". Therefore, it is very important to improve the structural and functional integrity of vascular endothelial cells and protect vascular endothelial cells in the treatment of vascular endothelial inflammation caused by vascular endothelial inflammation after angioplasty. Chinese herbal medicine has clear anti-inflammatory effect, which is of significance for improving the patency rate of lower extremity arterial lumen after treatment. Disease of coronary stenting in patients with lower extremity arteriosclerosis obliterans after ischemic symptoms, patients are often not treated by traditional Chinese medicine, research unit in the popliteal artery restenosis occurred at a higher rate, re intervention initially within 6 months, the incidence of up to and 3 to 6 months of little change. Early application of traditional Chinese medicine to improve the patency rate of blood vessels after endovascular treatment has become a necessary research topic. Therefore, it is necessary to study the effect of Supplementing Qi and activating blood on blood vessel, which is important to improve the patency rate after the operation and avoid the repeated operation and the lower limb ischemia.Purposes:To apply the Chinese medicine of Supplementing Qi and activating blood circulation to the patients with lower extremity arterial occlusive disease, and observe the patency rate and clinical effect(ankle branch index, TcPO2. Clinical symptom evaluation). To provide the clinical basis for the treatment of lower extremity arterial occlusive disease with the traditional Chinese medicine for the treatment of lower extremity arterial occlusive disease. And to explore new ways and provide a new method for the treatment of Chinese traditional medicine in the treatment of lower extremity arterial occlusive disease.Research method:According to statistics, the number of cases required to be calculated according to the rate of 20%, from March 2015 to February 2013 in our hospital patients with lower extremity arterial occlusive disease in 100 patients. The selected cases were randomly divided into A group (treatment group) and B group (control group), treatment for 90 days. Observation group after 3 months,6 months, ABI and TcPO2 and lower extremity artery color Doppler indexes.Results:A total of 88 cases were observed, and the patency rate of the two groups were significantly different after 6 months. The treatment group was significantly higher than that in the control group. There was no significant difference in TcPO2 between patients with restenosis and occlusion in A group.Conclusion:Early application of Yiqi Huoxue Jiedu can improve Artery Transluminal Angioplasty after vascular patency rate, at the same time, it can promote the establishment of collateral circulation, improve the local transcutaneous oxygen partial pressure, improve local circulation. When blood vessels appear to be re stenosis and occlusion, it can relieve the symptoms of ischemia, improve the local blood supply and improve the quality of life of patients.
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