| Primary osteoporosis (POP) is one kind of disease by low bone mineral density (BMD) and microstructure degeneration of bone tissue, leading to enhanced the bone- fragility and a consequent increase in fracture risk. Due to the increase of human being's life and formation of gerontal society, the osteoporosis and osteoporotic fracture, as one kind of the gerontal diseases, cause serious harm to people increasingly. As the increase of patients and the rise in price of health service, families and society are brought about the tremendous troubles in mind and economy. So the extensive attention is taken on the osteoporosis and the osteoporotic fracture in the world. The cause of the osteoporosis haven not been clarified yet at present, it is considered that they are associated with Hormone control, Nutritional state, Physical agent, Immune function, Genetic polarity and so on. It's pathogenesis is correlation with Coupling of bone resorption and bone formation, estrogen and androgen deficiency caused by hypogonadism are significant factors in postmenopausal osteoporosis (PMOP) and senile osteoporosis (SOP). There is not a term of "osteoporosis" in Traditional Chinese Medicine (TCM), the bone disease of TCM was recorded first in the Book Copied on Silk of Ma Wang Duei Han Tomb in the Spring and Autumn Period and the Warring States, and also recorded in the "Canon of Medicine","Essay on Typhoid" and so on. According to pathogenesis and clinical situation of osteoporosis, it look like Weidescribed in "Canon of Medicine" Ancient literature recorded it's Symptoms, Pathology, Therapy. Prognosis. Theory "Kidney controlling one" of TCM is key point in realization of osteoporosis by TCM. On basis of Theory "Kidney controlling one" Correlation of Spleen and Kidney, Blood Stasis and the bone's physiology and pathology, the cause of the bone disease, Professor Liu suggest that Spleen deficiency and Blood stasis is the important reason of osteoporosis too. About this he brought forward that kidney invigorating and bone strengthening, spleen strengthening and qi benefiting, activating blood circulation and removing blood stasis are the therapeutic principles of POP. According to preceding therapeutic principles of POP, Professor Liu designed a recipe composed of Chinese herbal medicine which named uKang Through a great quantity clinical observation, the effect of uKangis obviously. Clinical study 1.Study on bone mineral density and paramete of the bone metabolism changes in patients with soteoporosis To explore the role of Estrogen-2 (E2) and IL-6 in onset of osteoporosis, we chose 120 postmenopausal women . These women were divided into the two groups according to BMD: osteoporosis group (OP) and nonosteoporosis group (NOP). 60 normal pre-menopausal women were chose as the contrl group. The BMD, the serum levels of E2, Alkaline phosphatase (ALP), Osteocalcin (bone-carboxyglutamic acid-containing protein, BOP) and the Urinary hydroxyproline (U-HOP)! creatinine (Cr), Urinary Ca (U-Ca)/cr were were measured. The results showed that the level of BGP, ALP, IL-6 in post-menopausal women was significantly higher than that in the the control group (p<0.Ol), the level of the U-HOP/Cr and U-Ca/Cr was significantly higher that in the the control group t... |
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