Experimental Study On Mechanisms Of Tongluozhuyunfang Treated Rats Salpingitis Sterility

Purpose: To explore and make big rats modeI of sterilitycaused by chronic salpingitis, observe the effect ofTongluozhuyunfang (TLF in brief ) on the patho1ogy andmorphallaxis of oviduct, interleukin IL-2 \ IL-6 in serum andoviduct, and trace the rats pregnant rate for exploring its curativemechani sm.Methods: Mixed bacterium was used for making salpingitiscaused sterility rats model, treated by different doses of TLFcontrasted with Fuyankang (FYK ), the pathology and morpha1laxisof oviduct with Light and Transmission electron microscope wasobserved, the content of IL-2. IL-6 in serum and oviduct waschecked by ELISA method, pregnant results also was traced.Results: The fallopian tube of model rats was fOund with chronicsalpingitis, and result in sterility. TLF and FYK can resume thepathology and morphallaxis of oviduct in varying degrees, reduceIL-2. IL-6 both in serum and oviduct, and so raise the pregnantrate.Conclusion: Big rats model of sterility caused by chronicsalpingitis using mixed bacterium can be successfully made; thesterility is not caused by tubal obstruct completely, unbalance ofIL-2. IL-6 has relationship with this kind of sterility; TLF canimprove the tube structure and function, accommodate IL-2. IL-6both in serum and oviduct, and so has better therapy on thesterility.