Clinical And Experimental Study On Hyperthyroid Arrhythmia Treated By Kang Xin Ning Capsule

Clinical and experimental study had been made about hyperthyroid arrhythmia treated by Kang Xin Ning capsule in the article.SUMMARIZATION:(l)Traditional Chinese Medicine respectrFirst,through systematic reviewing and analysis,defined that hyperth-roid arrhythmia was belonged to TCM s "Ying Disease". However, shoud consult "Palpitation" and "Xiao Ke" in reality. Second, through comparing and analyzing experience of successive doctors, set forth Yu Zhong Xue professor's science thought about "deficiency of both qi and yin is the fundamental,stagnation of qi > phlegm-ecchymosis and pathogenic are the superficiality. Imbalance of heart-spirit is the important pathogenesis characteristic."(2)Western medicine respect:Seting forth the newest research progress in humoral immunity > cellular immunity > susceptibility of heredity > infective agent -, sexual hormone secretion > apoptosis> the action of iodine > myocardial damage > ACE ^ ET-1 and calciumion et al.Therapeutic methods which included in antithyroid drug N ?-receptor blocking agenU I31K surgery^ ACEI> and calcium antagonist had been analyzed.In the end conclused that arrhythmia was the seriousest and freque-ntest complication of hyperthyroidism. Hyperthyr-oidism belonged to autoimmune disease which was related to surroundings> emotions> infection and heredity et al. CLINICAL RESEARCH:We formulated case selection and curatve effect judgment standard according to concerned standard. " YingIVDisease " and " Palpitation " patients must be not only conformed to western medicine's hyperthyroid arrhythmia but also conformed to TCM s deficiency of both qi and yin> imbalance of heart-sprit.The 90 case were randomly distributed Kang Xin Ning capsule group -> TCM + western medicine group and western medicine group.The time of curative effect was 6 months.Through analyzing serum TT3 ^ TT4 ^ TSH,electrocardiogram,body weight,clinical symptom and curatire effect concluded that TCM of Kang Xing Ning campsule had the action of antithyrotoxic and protective heart.Kang Xin Ning group was better than western medicine in increasing weight and improving clinical symptom.The action of TCM+western medicine group was hot only rapid but also lasting.lt could reduce amount and toxicity of western medicine.Clinical curative effect was stabilized and reliable. EXPERIMENTAL RESEARCH:We successfully made rat model of hyperthyroid arrhythmia after consulting related documents. Accomplishing a lot of experiments such as serum TT^ TT4>; TSH, body weigh,heart rate,outward appearance,HE staining of thyroid gland and cardiac muscle,Masson staining of cardiac muscle,immunohistochemistry of cardiac muscle Myoglobin,expressing of cardiac muscle K+ passage's mRNA et al. Approached on the pathogenic factor and pathogenesis about hyperthyroid arrhythmia in pathology > molecule ^ gene standard. Seting forth the action mechanism of Kang Xin Ning capsule.