| Health and longevity is the eternal subject of existing and developing for human beings. With the developing of economy, the meliorating of medicine condition and the progressing of living standard, malignant tumor becomes one of the main diseases which do harm to health of people. There were about 10 million new cases of cancer in the world every year and about 6 million died from cancer. Furthermore, because of aging, smoking, changing of eating habit and developing of industry, the incidence rate and the death rate will continue increasing.Colorectal carcinoma was the third common malignancy and the second leading cause of cancer death in many developed countries. In China, the incidence of the colorectal cancer reaches to 35 to 50 cases per 1 million people each year and increases 2.40% every year, colorectal carcinoma ranks 4th common cancer and is 5th cause of cancer death.The therapeutic strategy for colorectal cancer is a comprehensive method including surgery, chemotherapy, radiotherapy, biological therapy and so on. But the whole cure rate of colorectal carcinoma was only about 50% in spite of using all these methods and the long-term survival rate and the quality of life were not satisfactied. To accelerate themaintaining development of economy and society, we should pay more attention to the chemoprevention strategy and look for more economic, more effective methods.Usually there are two ways to control cancer. The classical one, is treating patients with clinic symptoms which benefited in small part of patients. Another way is blocking the tumourigenesis with the chemoprevention strategy. The former was concentrating on eradicating cells that have already undergone malignant transformation, and the later was focusing on intervening in the process in the cascade of carcinogenic events to prevent the final progression to neoplastic disease. Compared with each other, the later is more promising. Carcinogenesis is a complex and multistage process which needs long time (more than 10-20 years), this situation offers the opportunity to interrupt or reverse tumor development at a still harmless stage. In addition, tumourigenesis involves interaction between genetics and environmental factors, and about 2/3 of tumors are related to environmental factors. To some extent, cancer is a kind of social disease. Preventing social disease should depend on prophylaxis.The chemoprevention of colorectal carcinoma has long history and a variety of agents have been purported to protect against colon cancer; of these, the non-steroidal anti-inflammatory drugs (NSAIDs) have demonstrated the greatest promise. The epidemiological and experimental evidence indicated that NSAIDs , such as, aspirin, sulindac et al, could reduce the risk of colorectal cancer by up to 50%. However, conventional NSAIDs taken orally inhibit both COX-1 and COX-2 nonselectively at concentrations encountered in the gastrointestinal tract. Thus, any of their beneficial effects on carcinogenesis, or other pathological process would be inseparable from the risk for adverse effects in gastrointestinal tract. So utilization of NSAIDs forcolon-cancer prevention has been hindered by their propensity to cause gastro-intestinal injury. To minimize the incidence of colon cancer, we need badly to seeking of novel high-effective, low-side-effect blocking agents. Some of agents have shown good prospect and got many eyeballs, such as, specif ic inhibitors of COX-2, gene prevention agents, telomerase inhibitors, differentiating inducers, apoptosis inducers and active components from nature products or traditional herbs.Chlorophyllin (CHL) is the derivative of nature chlorophyll and a mixture of sodium-copper salts that is marketed as an over-the-counter drug for controlling body, fecal, and urinary odor in geriatric and osteomy patients and as an accelerant in wound healing. It is also used extensively as a food additive for coloration. Recently, CHL has been shown to exert profound antimutagenic behavior against a wide range of potential hum...
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