Correlative Analysis Of Inflammatory Markers And Coronary Artery Lesions

In recent years it has been established that inflammation is a key role in the pathogenesis of atherosclerosis and in coronary artery disease progression. To study the relation of inflammatory markers and the severity of coronary lesions, and the predictive value of restenosis after coronary artery revascularization. We studied 94 case data of coronary angiography and measured plasma concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble platelet selectin,interleukin 6 (IL-6) and neopterin using an enzyme linked immunosorbent assay technique, high-sensitivity C-reactive protein (hs-CRP) with an immunophelometric assay. To search for the convenient and valid markers reflecting the severity of coronary artery lesions and prognoses. RESULTS Multiple regression analysis showed that hs-CRP levels correlated strongly with the levels of sVCAM-1, sICAM-1, P-selectin, IL-6 and neopterin (r=0.346,P=0.001; r=0.316, P=0.003; r=0.298, P=0.011; r=0.546,P＜0.0005; r=0.340,P＝0.001); Plasma concentrations of sICAM-1, sVCAM-1 and P-selectin were significant raised in coronary artery disease, these levels had a relation with the severity of coronary lesions. P-selectin levels were significantly raised in acute coronary syndrome (38.76(6.74ng/ml, P＜0.01), there is significantly difference with normal controls (19.54(1.72ng/ml). sICAM-1 levels was positively correlated with LDL (r=0.271, P=0.033), and sVCAM-1 with positively correlated with age and cholesterol (r=0.284, P=0.025. r=0.369,P=0.001); Plasma concentrations of hs-CRP were significantly raised in acute coronary syndrome (16.34(16.02mg/L), there was no difference in concentrations of hs-CRP between stable angina pectoris (2.76(2.31mg/L) and normal controls(1.07(1.12mg/L). Plasma concentrations of hs-CRP had significantly difference between the severity lesions, single vessel lesions, three vessel lesions, Gensini score(40 and normal controls. Hs-CRP levels was positively correlated with triglyceride level (r=0.533,P=0.002)and could predicted the restenosis after revascularization; Meanwhile the express of IL-6 was significantly higher in patient with coronary artery disease than in normal controls. But there was no difference in coronary artery disease groups; Plasma neopterin levels was significant increased in acute coronary syndrome (17.27(11.71ng/ml), there was no difference between stable angina pectoris (11.41(4.92 ng/ml) and normal controls(8.87(2.86ng/ml).CONCLUSIONS Inflammation is associated with coronary artery disease progression. Acute coronary syndrome was closely correlated with inflammation and immune activation. The results of our study lend further support to the notion that inflammatory processes may play a pathogenic role in atherosclerosis. To hint that acute coronary syndrome has inflammation and release acute phase proteins. The levels of hs-CRP, sICAM-1, sVCAM-1, P-selectin, IL-6 and neopterin may response inflammatory activity of atherosclerotic disease, and are markers of inflammation. Specialty the levels of hs-CRP and neopterin may be one of the markers of atherosclerotic activity. The levels hs-CRP has the predictive value of identification the acute coronary syndrome. It is necessity to study anti-inflammation treatment in stable atherosclerotic plaque.