Study On The Clinical Characteristics Of Latent Autoimmune Diabetes In Adults(LADA) And Microsatellite Allele A5.1 Of MICA Associated With LADA Of Chinese Patients In Tianjin

Objective: To investigate the frequency of GADA and ICA in patients initially diagnosed as type 2 DM. The clinical characteristic in patients with GADA(+),ICA(+),GADAICA(+). Methods: 482 inpatients and outpatients initially classified as type 2 DM who met all of the following criteria at diagnosis were recruited: age>30years,no history of ketonuria or ketoacidosis for >6 months after diagnosis, and not requiring insulin treatment at onset of disease. Serum antibodies to glutamic acid decarboxylase were determined by ELISA in all the patients. Serum antibodies to islet cell cytoplasmic antigens were determined by ELISA in part of the patients (including all the patients with GADA(+) and part of the patients with GADA(-)). Results: The overall prevalence of GADA was 14.73%,and ICA was 18.97%.2.70%were positive for 2 antibodies. There were no significant difference among the GADA+ group, ICA+group and GADAICA+group in age, sex, BMI and duration. There were no significant difference among the three groups in the levels of blood glucose and serum insulin of the OGTT0',30', 60',120', 180'.There were no significant difference among the three groups in the levels of plasma TC,TG,HDL-C,LDL-C and the prevalence of the 4 thyroid antibodidies (x2=1.80, 1.58, 0.29, 0.07, P>0.05) .Four cases of other autoimmune diseases were found in the patients with islet autoantibodies positive.Conclusion:In patients initially diagnosed as type 2 DM may in manycases suffer from LADA. Testing by GADA and ICA ELISA may be important in identifying LADA. Screening for other autoimmune diseases should be performed in all the type 2 DM patients with islet autoantibodies positive.