Risk Analyses And Studies On BSE Transmitted By Cosmetics Containing Bovine/Ovine-Derived Products

Cosmetic market is one of the fast developing consumption markets in China in recent years, and humans benefit much from cosmetics. Meanwhile, cosmetic consumption can also give rise to the problem of safety. Due to plenty of bovine/ ovine-derived ingredients being used in cosmetics, all the countries pay great attentions to the problem about whether cosmetics can transmit Bovine spongiform encephalopathy (BSE) because, as a serious zoonosis, the outbreak and spread of BSE can do great harm to people. Many countries have taken various measures to ban the import of bovine/ovine-derived products from countries or regions infected with BSE to protect humans from infecting with BSE. In order to prevent BSE pathogenies from introducing into our country, risk of transmitting BSE by cosmetics containing bovine/ovine-derived products was analyzed and studies in this article with the aim at supplying some basis in theory for legislating related rules of inspection and quarantine, giving some directions for cosmetic consumers and hoping to give some advice on strengthening the risk management of cosmetics with BSE infectivity. On the basis of current scientific knowledge, risk analysis model of transmitting BSE by cosmetics was set up with the theory of risk analysis from the respects of hazard identification, release assessment, exposure assessment, consequence assessment, risk assessment and risk management etc. in this study. The model consisted of geographically BSE risk (GBR) levels, animal health conditions, tissue origins, tissue infective levels, BSE infectivity inactivation or clearance levels in the production processes and the use of end-products. The model not only considered animal safeties and health conditions, but also emphatically analyzed BSE infectivity reduction or clearance levels in manufacturing processes of raw materials. Therefore, the model could meet the needs of Ministry of Health and General Administration of Quality Supervision, Inspection and Quarantine about "the safety assessment of cosmetic's ingredients related with BSE risk" in practice.By means of risk analyses and studies on BSE, the risk of transmitting BSE agent by cosmetic was confirmed in theory. So, Ban of 85 bovine/ovine-derived products or ingredients from the countries or regions infected with BSE to be used in cosmetics by Ministry of Health was based on science.According to the differences of levels of bringing and transmitting BSE, these 85 products or ingredients could be divided into three types, namely high-risk ingredients, middle-risk ingredients and low-risk ingredients, and were seperately assessed as the followings.For the high-risk ingredients, for example brain and spinal cord, the risk of transmitting BSE by them is great, so these materials should be inhibited to be used in cosmetics.For low-risk ingredients, the most typical examples was lanolins, they are mainly for external use in cosmetics. So if they were from health animals, and weren't contaminated by the specified risk materials (SRMs) and pH, tempreture and time in production process all reached certain criteria, the risk of transmitting BSE by the low-risk ingredients was generally neglectable.Middle-risk ingredients are complex and include 47 products, and the available information islimited, so only parts of whose production processes were known by us was analyzed here. For the production of greases, the raw materials removed SRMs of bovine/ovine were cut into particles with size of not more than 50mm and processed under the condition of 133/3bars/20minutes.lf the content of insoluble impurity was less than 0.15% and no cross-contamination happened in the process of storage and transportation, the grease produced were safe. For ossein and glutin ,if the raw materials were not contaminated, there were assays to identify the standards of production and no contamination with SRMs happened in the process, the ossein and glutin produced were also safe. For other proteins, glucide, grease and bio-monomolecular, their risk wasn't thoroughly assessed because the...