| Objective Extracellular matrix macromolecules are important for creating the cellular environments required during development and morphogenesis. Matrix metalloproteinases, collectively called matrixins, are proteinases that participate in ECM degradation. Under normal physiological conditions, the activities of MMPs are precisely regulated at the level of transcription, activation of the precursor zymogens, interaction with specific ECM components, and inhibition by endogenous inhibitors. A loss of activity control may result in diseases such as arthritis, cancer, atherosclerosis, aneurysms, nephritis, tissue ulcers, and fibrosis. Tissue inhibitors of metalloproteinases are specific inhibitors of matrixins that participate in controlling the local activities of MMPs in tissues. The pathological effects of MMPs and TIMPs in cardiovascular disease processes that involve vascular remodeling. To investigate the therapeutic effect of Rhodiola sachaliensis A.Bor. on rat model of glomerulosclerosis. Methods An experimental model of proliferative glomerulonephritis in the cat has been used to study the role of Rhodiola sachaliensis A.Bor. modulation extracellular matrix of glomerular in animal models. Results Rhodiola sachaliensis A.Bor. has potential therapeutic effects to proteinuria. The expression of FN and LN which is ECM components in glomeruli has decreased while PAI-1 increased after treatment. MMP-2, MMP-9 level in the peripheral blood decreased significantly after treatment TGF-(31 increased. Conclusions Rhodiola sachaliensis A. Bor. has a definite protective effect on glomerulosclerosis of the rat models.
|
PDF Full Text Request