The Study Of The Pathologic Evolution Of Infantile Hemangioma

Objective:To study the pathologic evolution of infantile hemangioma(IH). Method: (l)To observe the pathologic evolution of infantile hemangioma and the apoptosis.(2) To investigate the composition of IH cells by a series of maker antigens.(3)To investigate the distribution of T cell and its subsets and Dendritic cell and the expression of Fas/FasL protein and mRNA in IH. Results: (1) There are apoptotic endothelial cells througout the pathologic evolution of IH and there exists close relationship between the number of apoptotic cells and the total number of IH cells.(2)Endothelial cells and pericytes are the primary cells of 1H.(3) There exists obvious relation between the distribution of immunocytes and the expression of Fas/FasL and the apoptosis of IH cells. Conclusion:(l) The changes of the number of IH cells.the number and area of microvessels lead to the pathologic evolution of IH.The decrease of endothelial cells resulted from the apoptosis may be the major cause of the spontaneous involution of infantile hemangioma.(2)Endothelial cells and pericytes together' lead to vasculogenesis and its development.(3) The apoptosis of IH cells may be resulted from the immune response which is caused mainly by T cells and dendritic cells .aiming at the Fas antigen of IH cells and mediated byFas/FasL.